N6-Methyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H15N5O4
- MW
- 281.27
- Reinheit
- 99.75%
N6-Methyladenosine (m6A) is adenosine methylated at the adenine N6 position, corresponding to the nucleoside form of the RNA modification m6A. CH64084 is identified by CAS 1867-73-8, molecular formula C11H15N5O4, molecular weight 281.27, PubChem CID 102175, and InChIKey VQAYFKKCNSOZKM-IOSLPCCCSA-N.
The cited literature discusses m6A as the most abundant internal modification in mRNA and as an epitranscriptomic mark. Unlike acyl-protected building blocks, the N6-methyl group is a permanent base modification, not a removable protecting group.
Synonyme
N6-Methyladenosine; m6A; N6-methyl-rA
Identität und Spezifikationen
| Catalog No. | CH64084 |
| CAS No. | 1867-73-8 |
| Molecular Formula | C11H15N5O4 |
| Molecular Weight | 281.27 |
| PubChem CID | 102175 |
| InChIKey | VQAYFKKCNSOZKM-IOSLPCCCSA-N |
| Purity | 99.75% |
Lagerbedingungen
-20 C
Technische Merkmale
- Nucleobase
- Adenine
- Sugar
- D-Ribose
- Base modification
- N6-Methyl (m6A)
- Research role
- RNA epitranscriptomic-mark nucleoside reference
- Packaging
- 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 25 mg; supplied solution: 1 mL; Custom packaging on request
- Solution concentration
- Supplied solution: 10 mM x 1 mL in DMSO; solid-plus-solvent kit: 10 mM x 1 mL in DMSO ready for reconstitution
- Physical form
- crystalline solid
- Stability
- >=4 years
Anwendungskontext
- m6A epitranscriptomic-mark research: CH64084 is the nucleoside form of m6A, the RNA modification discussed in the cited literature as the most abundant internal mRNA modification.
- Base-modified nucleoside reference: CH64084 provides the N6-methyladenosine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 102175
PubChem · CID 102175
Häufig gestellte Fragen
Is the N6-methyl group a protecting group?
No. Unlike N6-acyl building blocks such as benzoyl- or 4-methoxybenzoyl-protected adenosine, the N6-methyl here is a permanent base modification and is not removed during deprotection.
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