N4-Benzoyl-2'-O-methylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C17H19N3O6
- MW
- 361.35
- Reinheit
- 99.21%
N4-Benzoyl-2'-O-methylcytidine is 2'-O-methylcytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64087 is identified by CAS 52571-45-6, molecular formula C17H19N3O6, molecular weight 361.35, PubChem CID 13852838, and InChIKey LIZIIHWLABYQKD-XKVFNRALSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Synonyme
N4-Benzoyl-2'-O-methylcytidine; N4-Bz-2'-OMe-rC; 2'-OMe-rC(Bz)
Identität und Spezifikationen
| Catalog No. | CH64087 |
| CAS No. | 52571-45-6 |
| Molecular Formula | C17H19N3O6 |
| Molecular Weight | 361.35 |
| PubChem CID | 13852838 |
| InChIKey | LIZIIHWLABYQKD-XKVFNRALSA-N |
| Purity | 99.21% |
Lagerbedingungen
2-8 C
Technische Merkmale
- Nucleobase
- Cytosine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N4-Benzoyl
- Synthesis role
- Base-protected 2'-O-methyl nucleoside intermediate
- Packaging
- 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 100 mg; supplied solution: 1 mL; Custom packaging on request
- Solution concentration
- Supplied solution: 10 mM x 1 mL in DMSO; solid-plus-solvent kit: 10 mM x 1 mL in DMSO ready for reconstitution
- Water content
- <=2.0%
- Physical form
- white to off-white powder
Anwendungskontext
- Base-protected 2'-OMe building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
- Nucleoside chemistry reference: CH64087 provides the N4-benzoyl-2'-O-methylcytidine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 13852838
PubChem · CID 13852838
Häufig gestellte Fragen
How does it differ from N4-benzoylcytidine?
Both carry an N4-benzoyl-protected cytosine, but this one also has a 2'-O-methyl sugar modification, whereas N4-benzoylcytidine has a free 2'-OH. N4-benzoylcytidine is cataloged separately.
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