N2-Isobutyryl-2'-O-methylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C15H21N5O6
- MW
- 367.36
- Reinheit
- 99.97%
N2-Isobutyryl-2'-O-methylguanosine is 2'-O-methylguanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64088 is identified by CAS 63264-29-9, molecular formula C15H21N5O6, molecular weight 367.36, PubChem CID 135536008, and InChIKey RPULCYXEYODQOG-AKAIJSEGSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Synonyme
N2-Isobutyryl-2'-O-methylguanosine; N2-ibu-2'-OMe-rG; 2'-OMe-rG(iBu)
Identität und Spezifikationen
| Catalog No. | CH64088 |
| CAS No. | 63264-29-9 |
| Molecular Formula | C15H21N5O6 |
| Molecular Weight | 367.36 |
| PubChem CID | 135536008 |
| InChIKey | RPULCYXEYODQOG-AKAIJSEGSA-N |
| Purity | 99.97% |
Lagerbedingungen
Powder: -20 C or 4 C; in solvent: -80 C or -20 C
Technische Merkmale
- Nucleobase
- Guanine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected 2'-O-methyl nucleoside intermediate
- Packaging
- 1 g; 5 g; Custom packaging on request
- Water content
- <=5.0%
- Physical form
- solid; white to off-white
- Stability
- Powder: 3 years at -20 C or 2 years at 4 C; in solvent: 6 months at -80 C or 1 month at -20 C
Anwendungskontext
- Base-protected 2'-OMe building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
- Nucleoside chemistry reference: CH64088 provides the N2-isobutyryl-2'-O-methylguanosine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 135536008
PubChem · CID 135536008
Häufig gestellte Fragen
How does it differ from N2-isobutyrylguanosine?
Both carry an N2-isobutyryl-protected guanine, but this one also has a 2'-O-methyl sugar modification, whereas N2-isobutyrylguanosine has a free 2'-OH. N2-isobutyrylguanosine is cataloged separately.
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