N4-Acetyl-2'-O-methylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C12H17N3O6
- MW
- 299.28
- Reinheit
- 99.62%
N4-Acetyl-2'-O-methylcytidine is 2'-O-methylcytidine whose cytosine exocyclic N4-amine is protected with an acetyl group. CH64090 is identified by CAS 113886-71-8, molecular formula C12H17N3O6, molecular weight 299.28, PubChem CID 10902616, and InChIKey CYDFBLGNJUNSCC-QCNRFFRDSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Synonyme
N4-Acetyl-2'-O-methylcytidine; N4-Ac-2'-OMe-rC; 2'-OMe-rC(Ac)
Identität und Spezifikationen
| Catalog No. | CH64090 |
| CAS No. | 113886-71-8 |
| Molecular Formula | C12H17N3O6 |
| Molecular Weight | 299.28 |
| PubChem CID | 10902616 |
| InChIKey | CYDFBLGNJUNSCC-QCNRFFRDSA-N |
| Purity | 99.62% |
Lagerbedingungen
+4 C
Technische Merkmale
- Nucleobase
- Cytosine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N4-Acetyl
- Synthesis role
- Base-protected 2'-O-methyl nucleoside intermediate
- Packaging
- 10 mg; 25 mg; 100 mg; 500 mg; 1 mL x 10 mM (in DMSO); Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Water content
- <=2.0%
- Physical form
- white to off-white powder
- Stability
- >=4 years
Anwendungskontext
- Base-protected 2'-OMe building block: the N4-acetyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
- Nucleoside chemistry reference: CH64090 provides the N4-acetyl-2'-O-methylcytidine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 10902616
PubChem · CID 10902616
Häufig gestellte Fragen
How does it differ from N4-benzoyl-2'-O-methylcytidine?
Both are 2'-O-methylcytidine with a protected cytosine N4-amine, but this one uses an acetyl group rather than benzoyl. The benzoyl form is cataloged separately.
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