N4-Acetyl-2'-fluoro-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H14FN3O5
- MW
- 287.24
- Reinheit
- >=99.0% (HPLC)
N4-Acetyl-2'-fluoro-2'-deoxycytidine is 2'-fluoro-2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with an acetyl group. CH64094 is identified by CAS 159414-97-8, molecular formula C11H14FN3O5, molecular weight 287.24, PubChem CID 22094552, and InChIKey NLXVKEFNBVLDLD-PEBGCTIMSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonyme
N4-Acetyl-2'-fluoro-2'-deoxycytidine; N4-Ac-2'-F-dC; 2'-F-rC(Ac)
Identität und Spezifikationen
| Catalog No. | CH64094 |
| CAS No. | 159414-97-8 |
| Molecular Formula | C11H14FN3O5 |
| Molecular Weight | 287.24 |
| PubChem CID | 22094552 |
| InChIKey | NLXVKEFNBVLDLD-PEBGCTIMSA-N |
| Purity | >=99.0% (HPLC) |
Lagerbedingungen
2-8 C; keep dark and dry
Technische Merkmale
- Nucleobase
- Cytosine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N4-Acetyl
- Synthesis role
- Base-protected 2'-fluoro nucleoside intermediate
- Packaging
- Custom packaging on request
- Water content
- <=5.0%
- Physical form
- white powder
- Stability
- In solvent: 6 months at -80 C or 1 month at -20 C
Anwendungskontext
- Base-protected 2'-F building block: the N4-acetyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- Nucleoside chemistry identity: a defined N4-acetyl-2'-fluoro-2'-deoxycytidine compound for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 22094552
PubChem · CID 22094552
Häufig gestellte Fragen
How does it differ from N4-benzoyl-2'-fluoro-2'-deoxycytidine?
Both are 2'-fluoro cytidines with a protected cytosine N4-amine, but this one uses an acetyl group rather than benzoyl. The benzoyl form is cataloged separately.
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