5'-O-DMT-2'-deoxyinosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C31H30N4O6
- MW
- 554.60
- Reinheit
- 99.40%
5'-O-DMT-2'-deoxyinosine is 2'-deoxyinosine (hypoxanthine base) carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group. CH64106 is identified by CAS 93778-57-5, molecular formula C31H30N4O6, molecular weight 554.60, PubChem CID 136192437, and InChIKey IYNGMVFRUKBGNM-OYUWMTPXSA-N.
It is a 5'-protected precursor for DNA phosphoramidite/oligonucleotide synthesis: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle. Because the hypoxanthine base has no exocyclic amine, no base protecting group is required.
Synonyme
5'-O-DMT-2'-deoxyinosine; 5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine; DMT-dI
Identität und Spezifikationen
| Catalog No. | CH64106 |
| CAS No. | 93778-57-5 |
| Molecular Formula | C31H30N4O6 |
| Molecular Weight | 554.60 |
| PubChem CID | 136192437 |
| InChIKey | IYNGMVFRUKBGNM-OYUWMTPXSA-N |
| Purity | 99.40% |
Lagerbedingungen
-20 C long-term
Technische Merkmale
- Nucleobase
- Hypoxanthine
- Sugar
- 2'-Deoxyribose
- 5'-O protection
- DMT (dimethoxytrityl)
- Base protection
- Unprotected
- Grade
- N (Normal)
- Packaging
- 5 g; 10 g; 50 g; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white to faint yellow powder
- Stability
- Prepared stock solution: 6 months at -80 C or 1 month at -20 C
Anwendungskontext
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each oligonucleotide chain-elongation cycle.
- No base protection needed: the hypoxanthine base has no exocyclic amine, so this building block requires no base protecting group.
- Phosphoramidite precursor context: a 5'-protected 2'-deoxyinosine precursor toward DNA phosphoramidite building blocks.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 136192437
PubChem · CID 136192437
Häufig gestellte Fragen
Why does 5'-O-DMT-2'-deoxyinosine have no base protecting group?
The hypoxanthine base of 2'-deoxyinosine has no reactive exocyclic amine, so it needs no base protection. Only the 5'-hydroxyl is protected with the acid-labile DMT group, which is removed at the start of each oligonucleotide chain-elongation cycle.
What base does 2'-deoxyinosine contain?
It contains hypoxanthine, the deaminated form of the adenine base. This record is the 5'-O-DMT-protected precursor.
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