5'-O-DMT-5-methyl-2'-O-methyluridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C32H34N2O8
- MW
- 574.6
- Reinheit
- >=98%
5'-O-DMT-5-methyl-2'-O-methyluridine is 2'-O-methyl-5-methyluridine (its base is 5-methyluracil) carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group. CH64119 is identified by CAS 153631-19-7, molecular formula C32H34N2O8, molecular weight 574.6, PubChem CID 10438068, and InChIKey VFLOXJCZWDDILQ-NODMTMHWSA-N.
It is a 2'-OMe-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity. Because the 5-methyluracil base has no exocyclic amine, no base protecting group is required.
Synonyme
5'-O-DMT-5-methyl-2'-O-methyluridine; 5'-O-DMT-2'-OMe-5-methyl-rU; DMT-2'-OMe-5Me-rU
Identität und Spezifikationen
| Catalog No. | CH64119 |
| CAS No. | 153631-19-7 |
| Molecular Formula | C32H34N2O8 |
| Molecular Weight | 574.6 |
| PubChem CID | 10438068 |
| InChIKey | VFLOXJCZWDDILQ-NODMTMHWSA-N |
| Purity | >=98% |
Lagerbedingungen
2-8 C
Technische Merkmale
- Nucleobase
- 5-Methyluracil
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-O-Methyl
- Base protection
- Unprotected
- Packaging
- 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white to off-white powder
Anwendungskontext
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-OMe modification context: cited literature discusses 2'-O-methyl residues in relation to nuclease resistance and RNA affinity.
- No base protection needed: the 5-methyluracil base has no exocyclic amine, so this building block requires no base protecting group.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 10438068
PubChem · CID 10438068
Häufig gestellte Fragen
How does it differ from 5'-O-DMT-2'-O-methyluridine?
This one has a 5-methyluracil base (an extra methyl on the base), whereas 5'-O-DMT-2'-O-methyluridine has a plain uracil base. That one is cataloged separately.
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