2'-F-Adenosine (Bz) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C47H51FN7O7P
- MW
- 875.9
- Reinheit
- 99.17%
2'-F-Adenosine (Bz) CE Phosphoramidite is the 2'-fluoro adenosine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-N6-benzoyl-2'-deoxyadenosine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65026 is identified by CAS 136834-22-5, molecular formula C47H51FN7O7P, molecular weight 875.9, PubChem CID 12042896, and InChIKey VCCMVPDSLHFCBB-MSIRFHFKSA-N.
Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonyme
DMT-2'-F-rA(Bz) phosphoramidite; 5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine 3'-CE phosphoramidite
Identität und Spezifikationen
| Catalog No. | CH65026 |
| CAS No. | 136834-22-5 |
| Molecular Formula | C47H51FN7O7P |
| Molecular Weight | 875.9 |
| PubChem CID | 12042896 |
| InChIKey | VCCMVPDSLHFCBB-MSIRFHFKSA-N |
| Purity | 99.17% |
Lagerbedingungen
-20 C
Technische Merkmale
- Monomer class
- 2'-fluoro RNA CE phosphoramidite
- Nucleobase
- Adenine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N6-Benzoyl
- Packaging
- 100 mg; 250 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 25 g; 100 g; 200 g; 500 g; Custom packaging on request
- Water content
- <=0.3%
- Physical form
- white to off-white powder
- Stability
- stable under recommended storage conditions
Anwendungskontext
- 2'-F RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- 2'-Fluoro sugar modification: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- 5'-DMT + N6-benzoyl protection: the acid-labile 5'-DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 12042896
PubChem · CID 12042896
Häufig gestellte Fragen
What does this 2'-F amidite do in RNA synthesis?
Its 3'-phosphoramidite couples to the growing chain, with 5'-DMT removed each cycle and N6-benzoyl removed at final deprotection. The product provides a 2'-fluoro adenosine phosphoramidite identity.
How does it relate to 5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine?
It is the phosphoramidite of that nucleoside: the 3'-hydroxyl has been converted to a 2-cyanoethyl N,N-diisopropyl phosphoramidite. The precursor is cataloged separately.
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