UNA-U CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C46H53N4O10P
- MW
- 852.9
- Reinheit
- 99%
UNA-U CE Phosphoramidite is the unlocked nucleic acid (UNA) uracil building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing a uracil base, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65062 is identified by CAS 1120329-48-7, molecular formula C46H53N4O10P, molecular weight 852.9, PubChem CID 100942372, and InChIKey MHRGEJFLFYZLJI-LZOZAVILSA-N.
The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain and the acid-labile 5'-DMT is removed each cycle. Because uracil has no exocyclic amine, no base protecting group is required.
Synonyme
UNA-U phosphoramidite; DMT-unlocked-uridine CE phosphoramidite
Identität und Spezifikationen
| Catalog No. | CH65062 |
| CAS No. | 1120329-48-7 |
| Molecular Formula | C46H53N4O10P |
| Molecular Weight | 852.9 |
| PubChem CID | 100942372 |
| InChIKey | MHRGEJFLFYZLJI-LZOZAVILSA-N |
| Purity | 99% |
Lagerbedingungen
-20 C
Technische Merkmale
- Monomer class
- UNA CE phosphoramidite
- Nucleobase
- Uracil
- Sugar topology
- C2'-C3' bond-opened ribose
- Base protection
- None required
- Grade
- N (Normal)
- Packaging
- 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; 5 kg; 10 kg; 25 kg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
Anwendungskontext
- UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
- No base protection needed: uracil has no exocyclic amine, so this monomer requires no base protecting group (only the acid-labile 5'-DMT, removed each cycle).
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 100942372
PubChem · CID 100942372
Häufig gestellte Fragen
Why does the UNA-U amidite have no base protecting group?
Uracil has no reactive exocyclic amine, so it needs no base protection. The monomer carries only the acid-labile 5'-O-DMT group (removed each cycle) and the reactive phosphoramidite coupling group.
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