2'-FANA-adenosine
(2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- (2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- MF
- C10H12FN5O3
- MW
- 269.23
- Reinheit
- 99.95%
2'-FANA-adenosine is a 2'F-ANA modified nucleoside: adenosine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 20227-41-2, molecular formula C10H12FN5O3, molecular weight 269.23, and PubChem CID 11065470.
The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70037 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.
Synonyme
2'-deoxy-2'-fluoro-arabino adenosine; 2'F-ANA adenosine
Identität und Spezifikationen
| Catalog No. | CH70037 |
| CAS No. | 20227-41-2 |
| Molecular Formula | C10H12FN5O3 |
| Molecular Weight | 269.23 |
| Exact Mass | 269.09241742 |
| PubChem CID | 11065470 |
| InChIKey | ZGYYPTJWJBEXBC-GQTRHBFLSA-N |
| Purity | 99.95% |
Lagerbedingungen
-20 C for powder; -80 C in solvent; protect from direct sunlight
Technische Merkmale
- Material class
- 2'F-ANA nucleoside
- Nucleobase
- Adenine
- Sugar configuration
- 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
- Protection state
- Unprotected
- Packaging
- 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg; 1 g; 10 mM in DMSO, 1 mL; solid plus solvent kit for 10 mM in DMSO, 1 mL; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Physical form
- White solid
- Stability
- 3 years at -20 C for powder; 1 year at -80 C in solvent
Anwendungskontext
- 2'F-ANA nucleoside reference: an adenosine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
- Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
- Oligonucleotide chemistry context: use the 2'F-ANA class name and identifiers when matching research catalog records or confirmed internal specifications.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 11065470
PubChem · CID 11065470
Häufig gestellte Fragen
What is 2'-FANA-adenosine?
2'-FANA-adenosine is a 2'-deoxy-2'-fluoroarabino adenosine modified nucleoside. Its adenosine base and arabino-configured 2'-fluoro sugar are confirmed by PubChem CID 11065470.
How is 2'F-ANA different from ribo 2'-F-RNA?
Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Is CH70037 a phosphoramidite monomer?
No. CH70037 is documented as the modified nucleoside 2'-FANA-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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