2'-FANA-uridine
1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- MF
- C9H11FN2O5
- MW
- 246.19
- Reinheit
- 98.36%
2'-FANA-uridine is a 2'F-ANA modified nucleoside: uridine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 69123-94-0, molecular formula C9H11FN2O5, molecular weight 246.19, and PubChem CID 3007908.
The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70041 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.
Synonyme
2'-deoxy-2'-fluoro-arabino uridine; 2'F-ANA uridine
Identität und Spezifikationen
| Catalog No. | CH70041 |
| CAS No. | 69123-94-0 |
| Molecular Formula | C9H11FN2O5 |
| Molecular Weight | 246.19 |
| Exact Mass | 246.06519962 |
| PubChem CID | 3007908 |
| InChIKey | UIYWFOZZIZEEKJ-PXBUCIJWSA-N |
| Purity | 98.36% |
Lagerbedingungen
-20 C or 4 C for powder; -80 C or -20 C in solvent
Technische Merkmale
- Material class
- 2'F-ANA nucleoside
- Nucleobase
- Uracil
- Sugar configuration
- 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
- Protection state
- Unprotected
- Packaging
- 100 mg; 200 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 10 mM x 1 mL in DMSO; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Physical form
- Solid
- Stability
- 3 years at -20 C or 2 years at 4 C for powder; 6 months at -80 C or 1 month at -20 C in solvent
Anwendungskontext
- 2'F-ANA nucleoside reference: a uridine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
- Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
- Oligonucleotide chemistry context: use the 2'F-ANA class name and identifiers when matching research catalog records or confirmed internal specifications.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 3007908
PubChem · CID 3007908
Häufig gestellte Fragen
What is 2'-FANA-uridine?
2'-FANA-uridine is a 2'-deoxy-2'-fluoroarabino uridine modified nucleoside. Its uridine base and arabino-configured 2'-fluoro sugar are confirmed by PubChem CID 3007908.
How is 2'F-ANA different from ribo 2'-F-RNA?
Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Is CH70041 a phosphoramidite monomer?
No. CH70041 is documented as the modified nucleoside 2'-FANA-uridine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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