2'-O-Propargyl-2-amino-adenosine
(2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
- MF
- C13H16N6O4
- MW
- 320.30
- Reinheit
- >=95%
2'-O-Propargyl-2-amino-adenosine is a modified nucleoside with a 2,6-diaminopurine base and a 2'-O-propargyl sugar substituent. Key identifiers include CAS 1451256-04-4, molecular formula C13H16N6O4, molecular weight 320.30, and PubChem CID 102339225.
The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in clickable sugar-residue and click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.
Synonyme
2'-O-propargyl-2-aminoadenosine; 2'-O-propargyl-2,6-diaminopurine riboside
Identität und Spezifikationen
| Catalog No. | CH70065 |
| CAS No. | 1451256-04-4 |
| Molecular Formula | C13H16N6O4 |
| Molecular Weight | 320.30 |
| Exact Mass | 320.12330301 |
| PubChem CID | 102339225 |
| InChIKey | AGYDCNMIAHDTSH-WOUKDFQISA-N |
| Structural Note | 2,6-diaminopurine nucleoside with a 2'-O-propargyl sugar modification |
| Purity | >=95% |
Technische Merkmale
- Material class
- 2'-O-propargyl nucleoside
- Nucleobase
- 2,6-Diaminopurine
- Sugar modification
- 2'-O-propargyl
- Conjugation handle
- Terminal alkyne
- Packaging
- Custom packaging on request
Anwendungskontext
- Clickable sugar-residue research: literature reports 2'-O-propargylated 2-aminoadenosine in oligonucleotides with clickable sugar residues and bifunctional azide chemistry.
- Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for click-compatible oligonucleotide research workflows.
- Modified-nucleoside reference: use as a structure and identifier reference for 2'-O-propargyl 2-aminoadenosine chemistry.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 102339225
PubChem · CID 102339225
Häufig gestellte Fragen
What is 2'-O-Propargyl-2-amino-adenosine?
It is a modified nucleoside: a 2,6-diaminopurine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 1451256-04-4 under stereospecific CID 102339225.
What does the propargyl group add?
The 2'-O-propargyl group provides a terminal alkyne handle, which is why this type of nucleoside appears in clickable sugar-residue and click-compatible oligonucleotide chemistry studies.
Is CH70065 a phosphoramidite monomer?
No. CH70065 is documented as the modified nucleoside 2'-O-Propargyl-2-amino-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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