2'-O-Propargyl-adenosine
(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
- MF
- C13H15N5O4
- MW
- 305.29
- Reinheit
- 98%
2'-O-Propargyl-adenosine is a modified adenosine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 151390-97-5, molecular formula C13H15N5O4, molecular weight 305.29, and PubChem CID 22885207.
The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.
Synonyme
2'-O-propargyladenosine; 2'-O-propargyl adenosine
Identität und Spezifikationen
| Catalog No. | CH70066 |
| CAS No. | 151390-97-5 |
| Molecular Formula | C13H15N5O4 |
| Molecular Weight | 305.29 |
| Exact Mass | 305.11240398 |
| PubChem CID | 22885207 |
| InChIKey | ROHGEAZREAFNTO-QYVSTXNMSA-N |
| Structural Note | Adenosine nucleoside with a 2'-O-propargyl sugar modification |
| Purity | 98% |
Lagerbedingungen
-20 C for powder; -80 C in solvent
Technische Merkmale
- Material class
- 2'-O-propargyl nucleoside
- Nucleobase
- Adenine
- Sugar modification
- 2'-O-propargyl
- Conjugation handle
- Terminal alkyne
- Grade
- N (Normal)
- Packaging
- 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; Custom packaging on request
- Physical form
- Solid
- Stability
- 3 years at -20 C for powder; 1 year at -80 C in solvent
Anwendungskontext
- Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation and DNA click-modification contexts.
- Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
- Modified-nucleoside reference: use as a structure and identifier reference for 2'-O-propargyl adenosine chemistry.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 22885207
PubChem · CID 22885207
Häufig gestellte Fragen
What is 2'-O-Propargyl-adenosine?
It is a modified adenosine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 151390-97-5 under stereospecific CID 22885207.
What does the propargyl group add?
The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide chemistry contexts.
Is CH70066 a phosphoramidite monomer?
No. CH70066 is documented as the modified nucleoside 2'-O-Propargyl-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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