2'-O-Propargyl-cytidine
4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidin-2-one
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidin-2-one
- MF
- C12H15N3O5
- MW
- 281.26
- Reinheit
- 99% (HPLC)
2'-O-Propargyl-cytidine is a modified cytidine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 206552-85-4, molecular formula C12H15N3O5, molecular weight 281.26, and PubChem CID 22885208.
The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.
Synonyme
2'-O-propargylcytidine; 2'-O-propargyl cytidine
Identität und Spezifikationen
| Catalog No. | CH70067 |
| CAS No. | 206552-85-4 |
| Molecular Formula | C12H15N3O5 |
| Molecular Weight | 281.26 |
| Exact Mass | 281.10117059 |
| PubChem CID | 22885208 |
| InChIKey | FJGRSBJPLPTKDE-QCNRFFRDSA-N |
| Structural Note | Cytidine nucleoside with a 2'-O-propargyl sugar modification |
| Purity | 99% (HPLC) |
Lagerbedingungen
10-25 C; cool dry and well ventilated
Technische Merkmale
- Material class
- 2'-O-propargyl nucleoside
- Nucleobase
- Cytosine
- Sugar modification
- 2'-O-propargyl
- Conjugation handle
- Terminal alkyne
- Packaging
- 10 mg; 25 mg; 50 mg; 100 mg; 1 g; 5 g; 10 g; 50 g; 100 g; 1 kg; Custom packaging on request
- Physical form
- Powder
Anwendungskontext
- Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation and DNA click-modification contexts.
- Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
- Modified-cytidine reference: use as a structure and identifier reference for 2'-O-propargyl cytidine chemistry.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 22885208
PubChem · CID 22885208
Häufig gestellte Fragen
What is 2'-O-Propargyl-cytidine?
It is a modified cytidine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 206552-85-4 as CID 22885208.
What does the propargyl group add?
The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide chemistry contexts.
Is CH70067 a phosphoramidite monomer?
No. CH70067 is documented as the modified nucleoside 2'-O-Propargyl-cytidine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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