DMT-2'-O-TBDMS-N1-Me-Pseudouridine-CE
3-[[(2R,3R,4S,5S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- 3-[[(2R,3R,4S,5S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
- MF
- C46H63N4O9PSi
- MW
- 875.1
- Reinheit
- >=98.0% (NMR)
DMT-2'-O-TBDMS-N1-Me-Pseudouridine-CE is mapped to a protected N1-methylpseudouridine CE phosphoramidite. PubChem CID 167312621 records CAS 875302-45-7, molecular formula C46H63N4O9PSi, molecular weight 875.1, exact mass 874.41019313, and InChIKey ZDZLHJPETUXZJT-NSASEYFNSA-N.
The molecule combines a 5'-DMT-protected hydroxyl, a 2'-O-TBDMS-protected ribose hydroxyl, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. This makes it a protected N1-methylpseudouridine monomer for research workflows involving modified RNA oligonucleotide synthesis.
Synonyme
5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite; N1-Methylpseudouridine CEP; DMT-2'-O-TBDMS-N1-Me-Pseudouridine-CE (source name)
Identität und Spezifikationen
| Catalog No. | CH70379 |
| Product Name | DMT-2'-O-TBDMS-N1-Me-Pseudouridine-CE |
| CAS No. | 875302-45-7 |
| PubChem CID | 167312621 |
| Molecular Formula | C46H63N4O9PSi |
| Molecular Weight | 875.1 |
| Exact Mass | 874.41019313 |
| InChIKey | ZDZLHJPETUXZJT-NSASEYFNSA-N |
| Synonyms | 5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite; N1-Methylpseudouridine CEP |
| Purity | >=98.0% (NMR) |
Lagerbedingungen
-20 C
Technische Merkmale
- Monomer class
- N1-methylpseudouridine CE phosphoramidite
- Nucleoside identity
- N1-Methylpseudouridine
- 2'-O protection
- TBDMS
- Coupling group
- 3'-O-CE phosphoramidite
- Packaging
- 25 mg; 250 mg; 250 mg (ABI 10 mL / 20 mm septum); 250 umol (ABI 10 mL / 20 mm septum); 500 mg (ABI 10 mL / 20 mm septum); Custom packaging on request
- Physical form
- White - pale yellow, crystals - powder
- Stability
- Powder: 2 years; in solution at -20 C: 6 months; in solution at -80 C: 1 year
Anwendungskontext
- Protected CE phosphoramidite monomer: a protected N1-methylpseudouridine building block for solid-phase RNA oligonucleotide synthesis research.
- 2'-O-TBDMS RNA building block: the TBDMS group protects the ribose 2'-hydroxyl in RNA phosphoramidite workflows.
- Modified pseudouridine oligonucleotide research: supports research contexts requiring an N1-methylpseudouridine phosphoramidite identity.
Weitere Materialinformationen
Verwendung
Use as a research phosphoramidite identity in workflows involving protected N1-methylpseudouridine monomers, modified RNA oligonucleotide synthesis, or 2'-O-TBDMS RNA building-block selection.
Eigenschaften
CH70379 is a phosphoramidite form of protected N1-methylpseudouridine. It is distinct from protected nucleoside intermediates that do not carry the CE phosphoramidite group.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 167312621
PubChem · CID 167312621
Häufig gestellte Fragen
What is DMT-2'-O-TBDMS-N1-Me-Pseudouridine-CE?
It is a protected N1-methylpseudouridine CE phosphoramidite. PubChem CID 167312621 maps CAS 875302-45-7 to this protected phosphoramidite identity.
What protecting groups does this monomer contain?
The PubChem structure contains a 5'-DMT-protected hydroxyl and a 2'-O-TBDMS-protected ribose hydroxyl, plus a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group.
Is this the same as 5'-O-DMT-2'-O-TBDMS-N1-methyl-pseudouridine?
No automatic equivalence is assumed. CH70379 is the CE phosphoramidite form under CAS 875302-45-7; the protected nucleoside without the phosphoramidite group is a different identity.
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