L-rU CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C45H61N4O9PSi
- MW
- 861.0
- Reinheit
- >=98%
L-rU CE Phosphoramidite is a mirror-image RNA building block: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-L-uridine 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. It is identified by CAS 144490-31-3, molecular formula C45H61N4O9PSi, molecular weight 861.0, PubChem CID 101037436, and InChIKey SKNLXHRBXYGJOC-BKOBKXGTSA-N.
It is the enantiomer of the natural D-uridine amidite — built on L-ribose rather than D-ribose — so it has the same molecular formula and weight as its D-counterpart. The cited mirror-image oligonucleotide literature provides background for L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality. Uracil has no exocyclic amine, so no base protecting group is needed; the 2'-O-TBDMS group protects the 2'-hydroxyl and the 5'-DMT is removed each cycle.
Synonyme
5'-O-DMT-2'-O-TBDMS-L-uridine 3'-CE phosphoramidite; L-ribouridine (mirror-image) amidite
Identität und Spezifikationen
| Catalog No. | CH65089 |
| CAS No. | 144490-31-3 |
| Molecular Formula | C45H61N4O9PSi |
| Molecular Weight | 861.0 |
| PubChem CID | 101037436 |
| InChIKey | SKNLXHRBXYGJOC-BKOBKXGTSA-N |
| Purity | >=98% |
Lagerbedingungen
-20 C
Technische Merkmale
- Monomer class
- 2'-O-TBDMS L-RNA CE phosphoramidite
- Nucleobase
- Uracil
- Sugar configuration
- L-ribose
- Base protection
- None required
- Grade
- N (Normal)
- Packaging
- 100 mg; 200 mg; 250 mg; 1 g; 5 g; 10 g; 25 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
Anwendungskontext
- Mirror-image (L-ribose) monomer: provides the L-uridine subunit identity for L-RNA synthesis.
- Mirror-image literature context: cited literature supports L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality.
- RNA protection scheme: 2'-O-TBDMS protects the 2'-hydroxyl and the 5'-DMT is removed each cycle; uracil needs no base protection.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 101037436
PubChem · CID 101037436
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