Spacer-18 (Hexaethylene Glycol) Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C42H61N2O10P
- MW
- 784.9
- Reinheit
- 99%
Spacer-18 (Hexaethylene Glycol) Phosphoramidite is a non-nucleotide (abasic) spacer building block: a hexaethylene glycol chain carrying a 5'-O-(4,4'-dimethoxytrityl) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 125607-09-2, molecular formula C42H61N2O10P, molecular weight 784.9, and PubChem CID 22904875.
Coupling inserts a long, flexible, polar non-nucleotide ethylene-glycol spacer into the oligonucleotide backbone in place of nucleotides. The cited hexaethylene glycol literature describes this chain type joining two complementary segments into a hairpin. The spacer couples through its 3'-phosphoramidite, and its 5'-DMT is removed each cycle so chain assembly continues.
Synonyme
Spacer 18; hexaethylene glycol spacer phosphoramidite; DMT-O-(hexaethylene glycol)-3'-CE phosphoramidite
Identität und Spezifikationen
| Catalog No. | CH65100 |
| CAS No. | 125607-09-2 |
| Molecular Formula | C42H61N2O10P |
| Molecular Weight | 784.9 |
| PubChem CID | 22904875 |
| InChIKey | ZTCKUVQHKIMCLI-UHFFFAOYSA-N |
| Purity | 99% |
Lagerbedingungen
-20 C in dark; desiccate; protect from prolonged light
Technische Merkmale
- Reagent class
- Non-nucleotide spacer phosphoramidite
- Spacer type
- Hexaethylene glycol
- Ethylene glycol units
- 6
- End protection
- 5'-O-DMT
- Grade
- N (Normal)
- Packaging
- 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 kg; 10 kg; 100 µmol; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- colorless/yellowish oil
- Stability
- 12 months after receipt under stated storage
Anwendungskontext
- Long flexible ethylene-glycol spacer: introduces a long, polar hexaethylene glycol abasic spacer into the oligonucleotide backbone in place of nucleotides.
- Hairpin loop: a hexaethylene glycol chain can join two complementary segments into a hairpin loop.
- Chain-compatible: couples through a 3'-phosphoramidite and carries a 5'-DMT that is removed each cycle, so synthesis can continue past the spacer.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 22904875
PubChem · CID 22904875
Häufig gestellte Fragen
What is the Spacer-18 (hexaethylene glycol) phosphoramidite?
It is a non-nucleotide (abasic) spacer built on a hexaethylene glycol chain. Coupling inserts a long, flexible, polar ethylene-glycol spacer into the oligonucleotide backbone in place of nucleotides.
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