Solid Chemical Phosphorylation Reagent II
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C37H49N4O7P
- MW
- 692.8
- Reinheit
- 98% (HPLC)
Solid Chemical Phosphorylation Reagent II is a non-nucleoside building block for introducing a phosphate group on an oligonucleotide during synthesis: a phosphoramidite carrying a protected phosphate (with a 5'-O-(4,4'-dimethoxytrityl) handle) plus a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite, listed as a solid form. Its PubChem-backed identity includes CAS 202284-84-2, molecular formula C37H49N4O7P, molecular weight 692.8, and PubChem CID 139401737.
It couples at the oligonucleotide terminus like any amidite; after the phosphate protecting group is removed during deprotection, it leaves a phosphate monoester — for example a 5'-phosphate — chemically, without an enzymatic step. "Solid" identifies the catalog display form for this item.
Synonyme
Solid CPR II; solid chemical phosphorylation reagent II; 5'-phosphate-ON reagent (solid form)
Identität und Spezifikationen
| Catalog No. | CH65103 |
| CAS No. | 202284-84-2 |
| Molecular Formula | C37H49N4O7P |
| Molecular Weight | 692.8 |
| PubChem CID | 139401737 |
| InChIKey | HAUCJKGKHJPPNN-UHFFFAOYSA-N |
| Purity | 98% (HPLC) |
Lagerbedingungen
-20 C
Technische Merkmale
- Reagent class
- Non-nucleoside phosphorylation phosphoramidite
- Installation site
- Oligonucleotide terminus
- Installed group
- Phosphate monoester after deprotection
- Reagent form
- Solid-form reagent II
- Packaging
- 1 mg; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 kg; 10 kg; 50 kg; 100 µmol; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- solid
- Stability
- LK2127 solution: stable for 2 to 3 days
Anwendungskontext
- Solid Chemical Phosphorylation Reagent II reference: use this chemical phosphorylation reagent record for oligonucleotide phosphorylation reagent catalog work.
- Identifier cross-check: compare CAS 202284-84-2, PubChem CID 139401737, formula C37H49N4O7P, MW 692.8, and the listed InChIKey for catalog identity matching.
- Inquiry preparation: include catalog number CH65103, the product name, and the identity-matching identifiers when preparing a CHEMOS product inquiry.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 139401737
PubChem · CID 139401737
Häufig gestellte Fragen
What does Solid Chemical Phosphorylation Reagent II do?
It provides a phosphate group on an oligonucleotide chemically, during solid-phase synthesis, instead of using an enzyme (kinase). It couples like an amidite and, after deprotection, leaves a phosphate monoester — for example a 5'-phosphate.
What does 'Solid' mean here?
It denotes the catalog display form of the reagent for this item.
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