2'-MOE-A (Bz) 3'-Succinate, Triethylammonium Salt
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C45H45N5O11
- MW
- 831.9
- Reinheit
- >=98.0% (HPLC)
2'-MOE-A (Bz) 3'-Succinate, Triethylammonium Salt is a support-loading precursor for oligonucleotide synthesis: 5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2'-O-(2-methoxyethyl)adenosine 3'-O-succinate, listed as its triethylammonium salt. Its PubChem-backed succinate identity includes CAS 444814-78-2, molecular formula C45H45N5O11, molecular weight 831.9, and PubChem CID 168447036.
Unlike a phosphoramidite, this reagent carries a 3'-O-succinate half-ester rather than a coupling group. The succinate is the conventional linker for attaching the 3'-terminal 2'-MOE nucleoside to an amino-functionalized solid support (such as controlled-pore glass), so that chain assembly starts from this residue. The succinyl linkage is base-cleavable and is broken during deprotection to release the finished oligonucleotide; cited 2'-MOE literature provides the RNA-binding and nuclease-stability context, while 5'-DMT protects the 5'-hydroxyl and N6-benzoyl protects the adenine amine.
Synonyme
DMT-2'-MOE-A(Bz)-3'-succinate TEA salt; 5'-O-DMT-N6-Bz-2'-O-(2-methoxyethyl)adenosine-3'-O-succinyl triethylammonium salt
Identität und Spezifikationen
| Catalog No. | CH65119 |
| CAS No. | 444814-78-2 |
| Molecular Formula | C45H45N5O11 (succinate) |
| Molecular Weight | 831.9 |
| PubChem CID | 168447036 |
| InChIKey | QDFWOVDXCRSHLI-NPHJKCPPSA-N |
| Purity | >=98.0% (HPLC) |
Lagerbedingungen
-20 C; tightly closed; protected from humidity
Technische Merkmale
- Reagent class
- 3'-O-succinate support-loading precursor
- Terminal residue
- 2'-O-MOE-A(Bz)
- Support linker
- Succinate half-ester
- Salt form
- Triethylammonium
- Packaging
- Custom packaging on request
- Physical form
- white, off-white to light yellow powder
Anwendungskontext
- 3'-terminal support loading: the 3'-O-succinate couples to an amino-functionalized solid support to immobilize the 3'-terminal 2'-MOE-A(Bz) residue.
- Base-cleavable linker: the succinyl ester is cleaved during deprotection, releasing the finished oligonucleotide from the support.
- 2'-O-MOE modification: cited 2'-MOE literature provides RNA-binding and nuclease-stability context for the 2'-O-(2-methoxyethyl) group; 5'-DMT protects the 5'-hydroxyl and N6-benzoyl protects the adenine amine.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 168447036
PubChem · CID 168447036
Häufig gestellte Fragen
Is this a phosphoramidite?
No. It is a 2'-MOE nucleoside 3'-O-succinate (a support-loading precursor), not a phosphoramidite. Its 3'-succinate half-ester attaches the 3'-terminal 2'-MOE residue to a solid support before chain assembly begins.
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