PROTAC
产品展示
| 产品编号 | 名称 | CAS号 | 结构式 | 分子量 | 购买 |
|---|---|---|---|---|---|
| CH56001 | Boc-NH-PEG2-C2-NH2 | 153086-78-3 |  | 248.32 | |
| CH56002 | Bis(2-bromoethyl) ether | 5414-19-7 |  | 231.91 | |
| CH56003 | Boc-NH-PEG2-CH2COOH | 108466-89-3 |  | 263.29 | |
| CH56004 | 2-Chloroethanamine hydrochloride | 870-24-6 |  | 115.99 | |
| CH56005 | Hexane-1,6-diol | 629-11-8 |  | 118.17 | |
| CH56006 | Azido-PEG4-alcohol | 86770-67-4 |  | 219.24 | |
| CH56007 | Ethyl hydroxyacetate | 623-50-7 |  | 104.1 | |
| CH56008 | Methyl 3-hydroxypropanoate | 6149-41-3 |  | 104.1 | |
| CH56009 | 2,2-Oxybis(ethylamine) | 2752-17-2 |  | 104.15 | |
| CH56010 | NH2-PEG4-CH2CH2COOH | 663921-15-1 |  | 265.3 |
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常见问题
PROTAC相关的定制合成、工艺开发、分析资料与项目沟通问题。
What is the difference between PROTACs and molecular glues?
PROTACs are bifunctional with a defined linker between target ligand and E3 recruiter. Molecular glues are monomeric small molecules that induce protein-protein interactions between target and E3 ligase without an obvious linker. Lenalidomide and pomalidomide are classic molecular glues that recruit CRBN to neosubstrates.
When should I use CRBN vs VHL E3 recruiters?
CRBN-based recruiters (pomalidomide, lenalidomide) are smaller and synthetically accessible but carry risk of IMiD-related off-target degradation. VHL recruiters (VH032/AHPC) avoid IMiD mechanisms but are larger. Choice depends on target, tissue expression of the E3, and resistance considerations.
What linker length is optimal for PROTAC activity?
Optimal linker length and composition are highly target-specific. Typical PROTAC libraries screen PEG2 through PEG6 linkers plus alkyl variants. Rigid or branched linkers can improve ternary complex geometry for some targets.
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