Sulfo-SMCC sodium
Sulfo-SMCC sodium
Résumé du produit
Aperçu rapide
- Famille de produits
- ADC Linkers & Conjugation Reagents
- Nom chimique
- Sulfo-SMCC sodium
- FM
- C16H17N2NaO9S
- PM
- 436.37
Sulfo-SMCC sodium is a water-soluble SMCC-type crosslinker identified by CAS 92921-24-9.
PubChem CID 4618794 and ChemicalBook support molecular formula C16H17N2NaO9S; ChemicalBook lists molecular weight 436.37, while PubChem rounds it as 436.4.
The page presents the compound through its sodium sulfonate, NHS ester, and maleimide functional-group context for research bioconjugation work.
Identité et spécifications
| Catalog No. | CH53019 |
| CAS No. | 92921-24-9 |
| Product Name | Sulfo-SMCC sodium |
| Synonyms | Sulfo-SMCC; Sulfo-SMCC sodium salt; Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt |
| Molecular Formula | C16H17N2NaO9S |
| Molecular Weight | 436.37 |
| PubChem CID | 4618794 |
| InChIKey | VUFNRPJNRFOTGK-UHFFFAOYSA-M |
| IUPAC Name | sodium 1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate |
Contexte d’application
- Crosslinker identity reference: matches Sulfo-SMCC sodium, Sulfo-SMCC, and sulfosuccinimidyl SMCC naming to CAS 92921-24-9.
- Bioconjugation research: PubMed and ChemicalBook sources describe Sulfo-SMCC in protein crosslinking and conjugation research.
- Functional-group comparison: useful for comparing NHS ester and maleimide crosslinker records in research-planning materials.
Informations complémentaires sur le matériau
Utilisations
Sulfo-SMCC sodium is a water-soluble SMCC-type research crosslinker identified by CAS 92921-24-9. Its NHS ester and maleimide groups make it relevant to crosslinker comparison and conjugation-method references.
Caractéristiques
- Sodium sulfonate form of an SMCC-type crosslinker.
- Contains NHS ester and maleimide functional groups in the same molecule.
- Formula C16H17N2NaO9S is consistent across PubChem and ChemicalBook.
Ressources techniques associées
Chimie des espaceurs et charges utiles pour ADC
Espaceurs clivables ou stables, segments hydrophiles, fonctions réactives sélectives et intermédiaires espaceur-charge utile.
espaceurs ADC clivables vs non clivables
Comparer espèce libérée, déclencheur, stabilité en circulation, traitement cellulaire, charge, conjugaison et preuves analytiques.
Sources publiques
- Sulfo-SMCC sodium | PubChem CID 4618794
- Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates
Bioconjugate Chemistry, 2016
Product-family technical context
- Effect of Linker-Drug Properties and Conjugation Site on the Physical Stability of ADCs
Journal of Pharmaceutical Sciences, 2020
Product-family technical context
- Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing
Cancer Research, 2006
Product-family technical context
- The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates
Molecular Cancer Therapeutics, 2012
Product-family technical context
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