2',3'-Dideoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C9H12N2O4
- PM
- 212.20
- Pureté
- >=98%
2',3'-Dideoxyuridine (ddU) is a pyrimidine 2',3'-dideoxynucleoside with uracil attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64019 is identified by CAS 5983-09-5, molecular formula C9H12N2O4, molecular weight 212.20, and PubChem CID 65161.
Its corresponding triphosphate, ddUTP, has been reported to be incorporated into a growing DNA chain at dTTP sites and to inhibit further elongation in an in vitro chain-termination study. This supports a narrow nucleic-acid research context for the dideoxynucleoside.
Synonymes
2',3'-Dideoxyuridine; ddU
Identité et spécifications
| Catalog No. | CH64019 |
| CAS No. | 5983-09-5 |
| Molecular Formula | C9H12N2O4 |
| Molecular Weight | 212.20 |
| PubChem CID | 65161 |
| InChIKey | BTOTXLJHDSNXMW-POYBYMJQSA-N |
| Purity | >=98% |
Conditions de stockage
0-10 C
Caractéristiques techniques
- Nucleobase
- Uracil
- Sugar
- 2',3'-Dideoxyribose
- Nucleoside class
- Pyrimidine dideoxynucleoside
- Research role
- Chain-terminator nucleotide precursor
- Packaging
- 250 mg; Custom packaging on request
- Physical form
- Solid; white to light yellow powder to crystal
- Stability
- >=4 years
Contexte d’application
- Chain-termination precursor: the corresponding ddUTP is reported to be incorporated into a growing DNA chain and inhibit further elongation in an in vitro study.
- Nucleic-acid research: ddU provides the uridine dideoxynucleoside identity for in vitro chain-termination comparisons.
- Dideoxynucleoside reference: CH64019 provides the 2',3'-dideoxyuridine identity for nucleoside chemistry comparisons.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 65161
PubChem · CID 65161
Questions fréquentes
What chain-termination evidence supports 2',3'-dideoxyuridine?
In an in vitro study, the corresponding ddUTP was incorporated into a growing DNA chain at dTTP sites and inhibited further elongation. This page keeps that evidence in a research-only context.
How is ddU different from 2'-deoxyuridine?
2'-Deoxyuridine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxyuridine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxyuridine is cataloged separately.
Produits similaires
Besoin d’aide pour sélectionner un matériau ?
CHEMOS peut examiner l’adéquation produit, la structure cible, les questions de voie, les attentes analytiques et les besoins d’approvisionnement du projet.