2'-O-Methylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C10H15N3O5
- PM
- 257.24
- Pureté
- >98.0% (HPLC, titration)
2'-O-Methylcytidine (2'-OMe-C, Cm) is cytidine with a 2'-O-methyl group on the ribose. CH64021 is identified by CAS 2140-72-9, molecular formula C10H15N3O5, molecular weight 257.24, and PubChem CID 150971.
The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while natural 2'-O-methylation is treated as an RNA-modification reference.
Synonymes
2'-O-Methylcytidine; 2'-OMe-C; Cm
Identité et spécifications
| Catalog No. | CH64021 |
| CAS No. | 2140-72-9 |
| Molecular Formula | C10H15N3O5 |
| Molecular Weight | 257.24 |
| PubChem CID | 150971 |
| InChIKey | RFCQJGFZUQFYRF-ZOQUXTDFSA-N |
| Purity | >98.0% (HPLC, titration) |
Conditions de stockage
0-10 C
Caractéristiques techniques
- Nucleobase
- Cytosine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified pyrimidine ribonucleoside
- Packaging
- 1 g listed size; 200 mg glass bottle with plastic insert; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
- Stability
- >=4 years
Contexte d’application
- Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
- RNA-modification reference: 2'-O-methylation occurs naturally in RNA, making CH64021 relevant to tRNA/rRNA modification research.
- 2'-OMe ribonucleoside reference: CH64021 provides the 2'-O-methylcytidine identity for nucleoside chemistry comparisons.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 150971
PubChem · CID 150971
Questions fréquentes
What does the 2'-O-methyl group do?
A 2'-O-methyl group on the ribose is associated with higher nuclease resistance while retaining RNA-binding affinity, so it is commonly studied in antisense and siRNA oligonucleotide research.
Is 2'-O-methylcytidine a natural RNA modification?
Yes. 2'-O-methylation (Cm) occurs naturally in tRNA and rRNA, so 2'-O-methylcytidine is also a reference in RNA-modification research.
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