2'-O-Methylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C11H15N5O5
- PM
- 297.27
- Pureté
- 99%
2'-O-Methylguanosine (2'-OMe-G, Gm) is guanosine with a 2'-O-methyl group on the ribose. CH64022 is identified by CAS 2140-71-8, molecular formula C11H15N5O5, molecular weight 297.27, and PubChem CID 135406950.
The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while Gm is treated as a natural RNA-modification reference.
Synonymes
2'-O-Methylguanosine; 2'-OMe-G; Gm
Identité et spécifications
| Catalog No. | CH64022 |
| CAS No. | 2140-71-8 |
| Molecular Formula | C11H15N5O5 |
| Molecular Weight | 297.27 |
| PubChem CID | 135406950 |
| InChIKey | OVYNGSFVYRPRCG-KQYNXXCUSA-N |
| Purity | 99% |
Conditions de stockage
0-10 C
Caractéristiques techniques
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified purine ribonucleoside
- Packaging
- 1 g listed size; 200 mg glass bottle with plastic insert; Custom packaging on request
- Water content
- <=7.0%
- Physical form
- Solid; white to almost white powder to crystal
- Stability
- >=4 years
Contexte d’application
- Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
- RNA-modification reference: Gm is a naturally occurring 2'-O-methyl RNA modification, making CH64022 relevant to tRNA/rRNA modification research.
- 2'-OMe ribonucleoside reference: CH64022 provides the 2'-O-methylguanosine identity for nucleoside chemistry comparisons.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 135406950
PubChem · CID 135406950
Questions fréquentes
Is Gm a natural RNA modification?
Yes. 2'-O-methylguanosine (Gm, e.g. Gm34) occurs naturally in tRNA and rRNA, so this compound is also a reference in RNA-modification research.
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