7-TFA-ap-7-Deaza-2',3'-dideoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C16H16F3N5O3
- PM
- 383.32
- Pureté
- >=98%
7-TFA-ap-7-Deaza-2',3'-dideoxyadenosine is a 2',3'-dideoxy 7-deazaadenosine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C7 position. CH64050 is identified by CAS 114748-71-9, molecular formula C16H16F3N5O3, molecular weight 383.32, PubChem CID 14630112, and InChIKey WUXCPWCITSUNMX-WDEREUQCSA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker, while the 2',3'-dideoxy sugar defines the chain-terminating nucleoside identity. The cited literature discusses amine-linker nucleosides and 7-deazapurine C7 functionalization in fluorescent labeling and DNA-sequencing research.
Synonymes
7-(3-trifluoroacetamidoprop-1-ynyl)-7-deaza-2',3'-dideoxyadenosine; 7-TFA-ap-c7-ddA
Identité et spécifications
| Catalog No. | CH64050 |
| CAS No. | 114748-71-9 |
| Molecular Formula | C16H16F3N5O3 |
| Molecular Weight | 383.32 |
| PubChem CID | 14630112 |
| InChIKey | WUXCPWCITSUNMX-WDEREUQCSA-N |
| Purity | >=98% |
Caractéristiques techniques
- Nucleobase analog
- 7-Deazaadenine
- Sugar
- 2',3'-Dideoxyribose
- C7 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 100 mg; 500 mg; Custom packaging on request
- Physical form
- Solid
Contexte d’application
- Labeled terminator research: CH64050 combines a 2',3'-dideoxy nucleoside identity with a C7 aminopropynyl linker for DNA-sequencing and labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64050 provides the 7-TFA-ap-7-deaza-2',3'-dideoxyadenosine identity for nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 14630112
PubChem · CID 14630112
Questions fréquentes
What do 'TFA' and 'ap' mean in the name?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at C7, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
Why is it a chain terminator?
It is a 2',3'-dideoxynucleoside, which is the sugar pattern associated with chain-terminator designs in DNA-sequencing research. CH64050 also carries a protected C7 amino-linker.
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