5-TFA-ap-2'-deoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C14H14F3N3O6
- PM
- 377.27
- Pureté
- 98%
5-TFA-ap-2'-deoxyuridine is 2'-deoxyuridine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C5 position of uracil. CH64053 is identified by CAS 115899-40-6, molecular formula C14H14F3N3O6, molecular weight 377.27, PubChem CID 10894132, and InChIKey HCKMZBZCHQQZRJ-IVZWLZJFSA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.
Synonymes
5-(3-trifluoroacetamidoprop-1-ynyl)-2'-deoxyuridine; 5-TFA-ap-dU
Identité et spécifications
| Catalog No. | CH64053 |
| CAS No. | 115899-40-6 |
| Molecular Formula | C14H14F3N3O6 |
| Molecular Weight | 377.27 |
| PubChem CID | 10894132 |
| InChIKey | HCKMZBZCHQQZRJ-IVZWLZJFSA-N |
| Purity | 98% |
Conditions de stockage
Room temperature
Caractéristiques techniques
- Nucleobase
- Uracil
- Sugar
- 2'-Deoxyribose
- C5 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 100 mg; 250 mg; 1 g; Custom packaging on request
Contexte d’application
- Internal-labeling research: CH64053 combines a 2'-deoxyuridine identity with a C5 aminopropynyl linker for oligonucleotide labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64053 provides the 5-TFA-ap-2'-deoxyuridine identity for nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 10894132
PubChem · CID 10894132
Questions fréquentes
What do 'TFA' and 'ap' mean in the name?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at the C5 position of uracil, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
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