5-TFA-ap-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C14H15F3N4O5
- PM
- 376.29
- Pureté
- 97%
5-TFA-ap-2'-deoxycytidine is 2'-deoxycytidine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C5 position of cytosine. CH64054 is identified by CAS 115899-38-2, molecular formula C14H15F3N4O5, molecular weight 376.29, PubChem CID 14768553, and InChIKey OKLUSVKQOCPUNW-IVZWLZJFSA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.
Synonymes
5-(3-trifluoroacetamidoprop-1-ynyl)-2'-deoxycytidine; 5-TFA-ap-dC
Identité et spécifications
| Catalog No. | CH64054 |
| CAS No. | 115899-38-2 |
| Molecular Formula | C14H15F3N4O5 |
| Molecular Weight | 376.29 |
| PubChem CID | 14768553 |
| InChIKey | OKLUSVKQOCPUNW-IVZWLZJFSA-N |
| Purity | 97% |
Conditions de stockage
2-8 C, protect from light
Caractéristiques techniques
- Nucleobase
- Cytosine
- Sugar
- 2'-Deoxyribose
- C5 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; 25 uL sample solution; Custom packaging on request
- Solution concentration
- 10 mM supplied sample solution
- Physical form
- A solid
Contexte d’application
- Internal-labeling research: CH64054 combines a 2'-deoxycytidine identity with a C5 aminopropynyl linker for oligonucleotide labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64054 provides the 5-TFA-ap-2'-deoxycytidine identity for nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 14768553
PubChem · CID 14768553
Questions fréquentes
What do 'TFA' and 'ap' mean in the name?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at the C5 position of cytosine, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
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