8-Hydroxy-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C10H13N5O5
- PM
- 283.24
- Pureté
- >=98%
8-Hydroxy-2'-deoxyguanosine (8-oxo-dG) is the C8-oxidized form of 2'-deoxyguanosine. CH64071 is identified by CAS 88847-89-6, molecular formula C10H13N5O5, molecular weight 283.24, PubChem CID 135440064, and InChIKey HCAJQHYUCKICQH-VPENINKCSA-N.
The cited oxidative-stress literature discusses 8-hydroxy-2'-deoxyguanosine as a form of oxidative DNA damage and a marker of cellular oxidative stress. CH64071 provides the 8-oxo-dG identity for oxidative DNA damage, oxidized nucleoside, and nucleoside chemistry research.
Synonymes
8-Hydroxy-2'-deoxyguanosine; 8-oxo-dG; 8-oxo-2'-deoxyguanosine; 8-OHdG
Identité et spécifications
| Catalog No. | CH64071 |
| CAS No. | 88847-89-6 |
| Molecular Formula | C10H13N5O5 |
| Molecular Weight | 283.24 |
| PubChem CID | 135440064 |
| InChIKey | HCAJQHYUCKICQH-VPENINKCSA-N |
| Purity | >=98% |
Conditions de stockage
-20 C
Caractéristiques techniques
- Nucleobase
- Oxidized guanine
- Sugar
- 2'-Deoxyribose
- Base modification
- 8-Hydroxy / 8-oxo
- Research role
- Oxidative-DNA-damage nucleoside reference
- Grade
- for Biochemistry
- Packaging
- 5 mg; 5 umol (~1.5 mg); 5 x 5 umol; Custom packaging on request
- Physical form
- crystalline solid
- Stability
- >=4 years
Contexte d’application
- Oxidative-DNA-damage marker research: the cited literature discusses 8-oxo-dG as a form of oxidative DNA damage and a marker of cellular oxidative stress.
- Oxidized nucleoside reference: CH64071 provides the 8-hydroxy-2'-deoxyguanosine identity for oxidized nucleoside and nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 135440064
PubChem · CID 135440064
Questions fréquentes
How does it differ from 2'-deoxyguanosine?
It is the C8-oxidized (8-oxo/8-hydroxy) form of 2'-deoxyguanosine, whereas 2'-deoxyguanosine is unmodified. 2'-deoxyguanosine is cataloged separately.
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