N2-Phenoxyacetylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C18H19N5O7
- PM
- 417.37
- Pureté
- >=98%
N2-Phenoxyacetylguanosine (rG PAc) is guanosine whose guanine exocyclic N2-amine is protected with a phenoxyacetyl (PAc) group. CH64085 is identified by CAS 119824-66-7, molecular formula C18H19N5O7, molecular weight 417.37, PubChem CID 135921574, and InChIKey FOOYAXZEBFXEJD-IWCJZZDYSA-N.
The cited oligonucleotide-synthesis literature discusses labile exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64085 provides the N2-phenoxyacetyl-protected guanosine identity for RNA building-block and nucleoside chemistry research.
Synonymes
N2-Phenoxyacetylguanosine; N2-PAc-rG; rG(PAc)
Identité et spécifications
| Catalog No. | CH64085 |
| CAS No. | 119824-66-7 |
| Molecular Formula | C18H19N5O7 |
| Molecular Weight | 417.37 |
| PubChem CID | 135921574 |
| InChIKey | FOOYAXZEBFXEJD-IWCJZZDYSA-N |
| Purity | >=98% |
Caractéristiques techniques
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Base protection
- N2-Phenoxyacetyl (PAc)
- Synthesis role
- Base-protected RNA nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g; 25 g; 100 g; Custom packaging on request
Contexte d’application
- Base-protected RNA building block: the N2-phenoxyacetyl (PAc) group masks the guanine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanosine (rG) monomer precursor context: CH64085 is the PAc-protected guanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64085 provides the N2-phenoxyacetylguanosine (rG PAc) identity for nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 135921574
PubChem · CID 135921574
Questions fréquentes
What is the 'PAc' group on this guanosine?
PAc is phenoxyacetyl. In CH64085, the group is on the guanine exocyclic N2-amine and is part of the base-protected guanosine identity.
How does it differ from N2-isobutyrylguanosine?
Both protect the guanine N2-amine, but this one uses a phenoxyacetyl (PAc) group rather than isobutyryl. N2-isobutyrylguanosine is cataloged separately.
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