N6-Benzoyl-2'-fluoro-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C17H16FN5O4
- PM
- 373.34
- Pureté
- 99.92%
N6-Benzoyl-2'-fluoro-2'-deoxyadenosine is 2'-fluoro-2'-deoxyadenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64091 is identified by CAS 136834-20-3, molecular formula C17H16FN5O4, molecular weight 373.34, PubChem CID 11760510, and InChIKey HLJZTLWDAQVZBU-YAMOITTJSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonymes
N6-Benzoyl-2'-fluoro-2'-deoxyadenosine; N6-Bz-2'-F-dA; 2'-F-rA(Bz)
Identité et spécifications
| Catalog No. | CH64091 |
| CAS No. | 136834-20-3 |
| Molecular Formula | C17H16FN5O4 |
| Molecular Weight | 373.34 |
| PubChem CID | 11760510 |
| InChIKey | HLJZTLWDAQVZBU-YAMOITTJSA-N |
| Purity | 99.92% |
Conditions de stockage
2-8 C; keep dark and dry
Caractéristiques techniques
- Nucleobase
- Adenine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected 2'-fluoro nucleoside intermediate
- Packaging
- 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; solution 1 mL x 10 mM in DMSO; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Water content
- <=2.0%
- Physical form
- white powder
- Stability
- Powder: 3 years at -20 C or 2 years at 4 C; in solvent: 6 months at -80 C or 1 month at -20 C
Contexte d’application
- Base-protected 2'-F building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-Fluoro sugar modification context: cited 2'-fluoro oligonucleotide literature discusses RNA affinity and nuclease resistance.
- Nucleoside chemistry reference: CH64091 provides the N6-benzoyl-2'-fluoro-2'-deoxyadenosine identity for nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 11760510
PubChem · CID 11760510
Questions fréquentes
How does it differ from N6-benzoyl-2'-O-methyladenosine?
Both are N6-benzoyl base-protected adenosines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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