N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C14H18FN5O5
- PM
- 355.32
- Pureté
- >=98.0% (HPLC)
N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine is 2'-fluoro-2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64093 is identified by CAS 80681-25-0, molecular formula C14H18FN5O5, molecular weight 355.32, PubChem CID 135742141, and InChIKey SLHADUUWJSVYGQ-HTFXMJNNSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonymes
N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine; N2-ibu-2'-F-dG; 2'-F-rG(iBu)
Identité et spécifications
| Catalog No. | CH64093 |
| CAS No. | 80681-25-0 |
| Molecular Formula | C14H18FN5O5 |
| Molecular Weight | 355.32 |
| PubChem CID | 135742141 |
| InChIKey | SLHADUUWJSVYGQ-HTFXMJNNSA-N |
| Purity | >=98.0% (HPLC) |
Conditions de stockage
2-8 C; keep dark and dry
Caractéristiques techniques
- Nucleobase
- Guanine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected 2'-fluoro nucleoside intermediate
- Packaging
- Custom packaging on request
- Water content
- <=2.0%
- Physical form
- white powder
Contexte d’application
- Base-protected 2'-F building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- Nucleoside chemistry identity: a defined N2-isobutyryl-2'-fluoro-2'-deoxyguanosine compound for nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 135742141
PubChem · CID 135742141
Questions fréquentes
How does it differ from N2-isobutyryl-2'-O-methylguanosine?
Both are N2-isobutyryl base-protected guanosines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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