2'-O-MOE-N2-Isobutyrylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C17H25N5O7
- PM
- 411.41
- Pureté
- >=98%
2'-O-MOE-N2-Isobutyrylguanosine is 2'-O-(2-methoxyethyl)guanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64098 is identified by CAS 440327-50-4, molecular formula C17H25N5O7, molecular weight 411.41, PubChem CID 136162613, and InChIKey IZOOGJIUOCHAAY-UBEDBUPSSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
Synonymes
2'-O-MOE-N2-Isobutyrylguanosine; 2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine; MOE-rG(iBu)
Identité et spécifications
| Catalog No. | CH64098 |
| CAS No. | 440327-50-4 |
| Molecular Formula | C17H25N5O7 |
| Molecular Weight | 411.41 |
| PubChem CID | 136162613 |
| InChIKey | IZOOGJIUOCHAAY-UBEDBUPSSA-N |
| Purity | >=98% |
Conditions de stockage
2-8 C
Caractéristiques techniques
- Nucleobase
- Guanine
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected MOE nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 10 g; 100 g; 1 kg; Custom packaging on request
- Water content
- <=2.0%
- Physical form
- white to off-white powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
Contexte d’application
- Base-protected 2'-O-MOE building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
- Nucleoside chemistry identity: a defined 2'-O-MOE-N2-isobutyrylguanosine compound for nucleoside chemistry research.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 136162613
PubChem · CID 136162613
Questions fréquentes
How does it differ from N2-isobutyryl-2'-O-methylguanosine?
Both are N2-isobutyryl base-protected guanosines, but this one has a 2'-O-methoxyethyl (2'-MOE) sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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