5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C38H34FN5O6
- PM
- 675.7
- Pureté
- 99.58%
5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine is 2'-fluoro-2'-deoxyadenosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N6-benzoyl base-protecting group. CH64122 is identified by CAS 136834-21-4, molecular formula C38H34FN5O6, molecular weight 675.7, PubChem CID 11125261, and InChIKey DDOOVEXTSRBCMU-VYUOYPLNSA-N.
It is a 2'-F-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N6-benzoyl group masks the adenine exocyclic amine and is removed at final deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonymes
5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine; 5'-O-DMT-2'-F-rA(Bz); DMT-2'-F-rA(Bz)
Identité et spécifications
| Catalog No. | CH64122 |
| CAS No. | 136834-21-4 |
| Molecular Formula | C38H34FN5O6 |
| Molecular Weight | 675.7 |
| PubChem CID | 11125261 |
| InChIKey | DDOOVEXTSRBCMU-VYUOYPLNSA-N |
| Purity | 99.58% |
Conditions de stockage
2-8 C
Caractéristiques techniques
- Nucleobase
- Adenine
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N6-Benzoyl
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 1 kg; 1 mL; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Water content
- <=1.0%
- Physical form
- white to off-white powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
Contexte d’application
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-Fluoro sugar modification: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- N6-benzoyl base protection: the benzoyl group masks the adenine exocyclic amine during synthesis and is removed at final deprotection.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 11125261
PubChem · CID 11125261
Questions fréquentes
How does it differ from N6-benzoyl-2'-fluoro-2'-deoxyadenosine?
Both carry an N6-benzoyl-protected 2'-fluoro adenosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.
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