N6-Methyl-2'-deoxyadenosine CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C41H50N7O6P
- PM
- 767.9
- Pureté
- >=98.0% (HPLC)
N6-Methyl-2'-deoxyadenosine CE Phosphoramidite is a DNA building block for 6mA-modified synthetic DNA research: 5'-O-(4,4'-dimethoxytrityl)-N6-methyl-2'-deoxyadenosine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65009 is identified by CAS 105931-58-6, molecular formula C41H50N7O6P, molecular weight 767.9, PubChem CID 86280297, and InChIKey PTWRBAYAPDVZGR-JNTXQERPSA-N.
It is a phosphoramidite coupling monomer for automated solid-phase DNA synthesis in which the base is N6-methyladenine (6mA): the 3'-phosphoramidite is the reactive group that couples to the growing chain, and the acid-labile 5'-DMT is removed at the start of each cycle. The N6-methyl group is the permanent 6mA base modification, not a removable protecting group.
Synonymes
DMT-N6-Me-dA phosphoramidite; 5'-O-DMT-N6-methyl-2'-deoxyadenosine 3'-CE phosphoramidite; 6mA amidite
Identité et spécifications
| Catalog No. | CH65009 |
| CAS No. | 105931-58-6 |
| Molecular Formula | C41H50N7O6P |
| Molecular Weight | 767.9 |
| PubChem CID | 86280297 |
| InChIKey | PTWRBAYAPDVZGR-JNTXQERPSA-N |
| Purity | >=98.0% (HPLC) |
Conditions de stockage
-20 C
Caractéristiques techniques
- Monomer class
- Modified DNA CE phosphoramidite
- Nucleobase
- Adenine
- 5'-O protection
- DMT (dimethoxytrityl)
- Base modification
- N6-Methyl (6mA)
- Packaging
- 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; Custom packaging on request
- Physical form
- solid
- Stability
- >=4 years
Contexte d’application
- 6mA DNA amidite: provides an N6-methyladenine (6mA) base identity for modified synthetic DNA research.
- DNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group is removed at the start of each chain-elongation cycle.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 86280297
PubChem · CID 86280297
Questions fréquentes
Is the N6-methyl group a protecting group?
No. The N6-methyl is the permanent N6-methyladenine (6mA) base modification. Only the acid-labile 5'-O-DMT group and the 3'-phosphoramidite coupling group are synthetic handles.
What base identity does this amidite provide?
It provides the N6-methyladenine (6mA) base identity for 6mA-modified synthetic DNA research via automated solid-phase phosphoramidite synthesis.
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