(S)-GNA-C(Ac) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C39H48N5O7P
- PM
- 729.8
- Pureté
- >=98.0% (HPLC)
(S)-GNA-C(Ac) CE Phosphoramidite is the glycol nucleic acid (GNA) cytosine building block for oligonucleotide synthesis: an (S)-propylene-glycol nucleoside bearing an N4-acetyl cytosine, a DMT-protected hydroxyl, and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65056 is identified by CAS 1159174-80-7, molecular formula C39H48N5O7P, molecular weight 729.8, PubChem CID 44196022, and InChIKey GJBIWQXFRRQYML-RRUDDRBXSA-N.
GNA is described in the cited literature as a simplified nucleic acid with an acyclic propylene glycol phosphodiester backbone, and the cited (S)-GNA literature discusses heteroduplex formation with RNA. As a phosphoramidite, the reactive phosphoramidite couples to the growing chain, the acid-labile DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.
Synonymes
(S)-GNA-C(Ac) phosphoramidite; DMT-(S)-glycol-N4-acetylcytosine CE phosphoramidite
Identité et spécifications
| Catalog No. | CH65056 |
| CAS No. | 1159174-80-7 |
| Molecular Formula | C39H48N5O7P |
| Molecular Weight | 729.8 |
| PubChem CID | 44196022 |
| InChIKey | GJBIWQXFRRQYML-RRUDDRBXSA-N |
| Purity | >=98.0% (HPLC) |
Conditions de stockage
-20 C
Caractéristiques techniques
- Monomer class
- (S)-GNA CE phosphoramidite
- Nucleobase
- Cytosine
- Backbone scaffold
- Glycol nucleic acid
- Base protection
- N4-acetyl
- Grade
- N (Normal)
- Packaging
- 10 mg; 25 mg; 50 mg; 100 mg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- powder 3 years; in solvent 1 year
Contexte d’application
- GNA coupling monomer: the (2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing GNA chain in solid-phase synthesis.
- Acyclic glycol backbone: GNA replaces the sugar-phosphate backbone with an acyclic propylene glycol phosphodiester backbone; the cited (S)-GNA literature discusses heteroduplex formation with RNA.
- DMT + N4-acetyl protection: the acid-labile DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 44196022
PubChem · CID 44196022
Questions fréquentes
How does it differ from the (S)-GNA-A(Bz) amidite?
Both are (S)-GNA phosphoramidites, but this one has an N4-acetyl-protected cytosine, whereas the (S)-GNA-A(Bz) amidite has an N6-benzoyl adenine. Each GNA base is cataloged separately.
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