L-rG (iBu) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C50H68N7O9PSi
- PM
- 970.2
- Pureté
- >=98%
L-rG (iBu) CE Phosphoramidite is a mirror-image RNA building block: 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-O-(tert-butyldimethylsilyl)-L-guanosine 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. It is identified by CAS 679809-76-8, molecular formula C50H68N7O9PSi, molecular weight 970.2, PubChem CID 172909778, and InChIKey PGJKESPHANLWME-ZEXYNXKFSA-N.
It is the enantiomer of the natural D-guanosine amidite — built on L-ribose rather than D-ribose — so it has the same molecular formula and weight as its D-counterpart. The cited mirror-image oligonucleotide literature provides background for L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality. The 2'-O-TBDMS group protects the 2'-hydroxyl, the 5'-DMT is removed each cycle, and the N2-isobutyryl base-protecting group is removed during final deprotection.
Synonymes
5'-O-DMT-N2-iBu-2'-O-TBDMS-L-guanosine 3'-CE phosphoramidite; L-riboguanosine (mirror-image) amidite
Identité et spécifications
| Catalog No. | CH65088 |
| CAS No. | 679809-76-8 |
| Molecular Formula | C50H68N7O9PSi |
| Molecular Weight | 970.2 |
| PubChem CID | 172909778 |
| InChIKey | PGJKESPHANLWME-ZEXYNXKFSA-N |
| Purity | >=98% |
Conditions de stockage
-20 C
Caractéristiques techniques
- Monomer class
- 2'-O-TBDMS L-RNA CE phosphoramidite
- Nucleobase
- Guanine
- Sugar configuration
- L-ribose
- Base protection
- N2-isobutyryl
- Grade
- N (Normal)
- Packaging
- 50 mg; 100 mg; 250 mg; 1 g; 25 g; 100 g; 500 g; 1 kg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
Contexte d’application
- Mirror-image (L-ribose) monomer: provides the L-guanosine subunit identity for L-RNA synthesis.
- Mirror-image literature context: cited literature supports L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality.
- RNA protection scheme: 2'-O-TBDMS protects the 2'-hydroxyl, the 5'-DMT is removed each cycle, and the N2-isobutyryl base-protecting group is removed during final deprotection.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 172909778
PubChem · CID 172909778
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