Spacer-C6 Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C36H49N2O5P
- PM
- 620.8
- Pureté
- >=98%
Spacer-C6 Phosphoramidite is a non-nucleotide (abasic) spacer building block: a six-carbon (hexyl) spacer carrying a 5'-O-(4,4'-dimethoxytrityl) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 158041-82-8, molecular formula C36H49N2O5P, molecular weight 620.8, and PubChem CID 117768145.
Coupling inserts a non-nucleotide six-carbon spacer into the oligonucleotide backbone in place of a nucleotide — non-nucleotide chains can be incorporated into oligonucleotides this way (for example, to join segments or introduce a defined gap). The spacer couples through its 3'-phosphoramidite, and its 5'-DMT is removed each cycle so chain assembly continues.
Synonymes
DMT-O-C6-spacer 3'-CE phosphoramidite; 6-(DMTO)hexyl non-nucleotide spacer amidite
Identité et spécifications
| Catalog No. | CH65097 |
| CAS No. | 158041-82-8 |
| Molecular Formula | C36H49N2O5P |
| Molecular Weight | 620.8 |
| PubChem CID | 117768145 |
| InChIKey | AEDFSPMNECTXJM-UHFFFAOYSA-N |
| Purity | >=98% |
Conditions de stockage
-20 C
Caractéristiques techniques
- Reagent class
- Non-nucleotide spacer phosphoramidite
- Spacer type
- Alkyl
- Spacer length
- 6 carbons
- End protection
- 5'-O-DMT
- Packaging
- 250 mg; 500 mg; 1 g; 5 g; 10 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- colourless transparent oily substance
Contexte d’application
- Non-nucleotide spacer insertion: introduces a six-carbon abasic spacer into the oligonucleotide backbone in place of a nucleotide.
- Chain-compatible: couples through a 3'-phosphoramidite and carries a 5'-DMT that is removed each cycle, so synthesis can continue past the spacer.
- Backbone linker: non-nucleotide chains can be incorporated into oligonucleotides to join segments or introduce a defined gap.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 117768145
PubChem · CID 117768145
Questions fréquentes
What is a spacer phosphoramidite?
It is a non-nucleotide (abasic) building block that inserts a spacer unit into the oligonucleotide backbone in place of a nucleotide. It couples through a 3'-phosphoramidite and carries a 5'-DMT (removed each cycle) so chain assembly continues normally.
What does the 'C6' mean?
C6 denotes the length of the spacer — a six-carbon (hexyl) chain. Shorter (C2, C3) and longer (C12) variants and ethylene-glycol spacers give correspondingly different spacings.
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