Spacer-9 (Triethylene Glycol) Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Résumé du produit
Aperçu rapide
- Famille de produits
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C36H49N2O7P
- PM
- 652.8
- Pureté
- >98%
Spacer-9 (Triethylene Glycol) Phosphoramidite is a non-nucleotide (abasic) spacer building block: a triethylene glycol chain carrying a 5'-O-(4,4'-dimethoxytrityl) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 146668-73-7, molecular formula C36H49N2O7P, molecular weight 652.8, and PubChem CID 56846264.
Coupling inserts a flexible, polar non-nucleotide ethylene-glycol spacer into the oligonucleotide backbone in place of a nucleotide — ethylene glycol chains can be incorporated into oligonucleotides this way (for example, joining two complementary segments into a hairpin loop, or introducing a defined gap). The spacer couples through its 3'-phosphoramidite, and its 5'-DMT is removed each cycle so chain assembly continues.
Synonymes
Spacer 9; triethylene glycol spacer phosphoramidite; DMT-O-(triethylene glycol)-3'-CE phosphoramidite
Identité et spécifications
| Catalog No. | CH65099 |
| CAS No. | 146668-73-7 |
| Molecular Formula | C36H49N2O7P |
| Molecular Weight | 652.8 |
| PubChem CID | 56846264 |
| InChIKey | PEJGGZVVBQPTRG-UHFFFAOYSA-N |
| Purity | >98% |
Conditions de stockage
-20 C
Caractéristiques techniques
- Reagent class
- Non-nucleotide spacer phosphoramidite
- Spacer type
- Triethylene glycol
- Ethylene glycol units
- 3
- End protection
- 5'-O-DMT
- Grade
- N (Normal)
- Packaging
- 250 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 1 kg; 5 kg; 100 µmol; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- colorless oily liquid
Contexte d’application
- Flexible ethylene-glycol spacer: introduces a polar, flexible triethylene glycol abasic spacer into the oligonucleotide backbone in place of a nucleotide.
- Segment linker / loop: ethylene glycol chains can join two complementary segments into a hairpin loop or introduce a defined gap.
- Chain-compatible: couples through a 3'-phosphoramidite and carries a 5'-DMT that is removed each cycle, so synthesis can continue past the spacer.
Ressources techniques associées
Sources publiques
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Composé PubChem 56846264
PubChem · CID 56846264
Questions fréquentes
What is the Spacer-9 (triethylene glycol) phosphoramidite?
It is a non-nucleotide (abasic) spacer built on a triethylene glycol chain. Coupling inserts a flexible, polar ethylene-glycol spacer into the oligonucleotide backbone in place of a nucleotide, for joining segments or introducing a defined gap.
How does it differ from the alkyl (C-series) spacers?
It uses an ethylene glycol (ether) chain rather than a pure hydrocarbon chain, making it more polar and flexible; the extra oxygens are reflected in its formula (C36H49N2O7P). Otherwise it couples the same way, via a 3'-phosphoramidite with a 5'-DMT removed each cycle.
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