Molecular Glues

Molecular glues are small molecules that promote or stabilize interactions between proteins that would otherwise not associate. By enhancing the binding between a target protein and an E3 ubiquitin ligase, molecular glues induce ubiquitination and proteasomal degradation of the target. Unlike bifunctional degraders, molecular glues rely on conformational stabilization rather than a linker to bring proteins together.

Molecular glues represent an emerging class of targeted protein degraders with relatively simple structures and favorable drug-like properties. Their ability to modulate protein–protein interactions opens new opportunities for targeting challenging disease-associated proteins. Ongoing discoveries in chemical biology are rapidly expanding the scope of molecular glue therapeutics across oncology and other disease areas.

产品展示

产品编号	名称	CAS号	分子量
CH57001	1-(4-Bromo-2-chlorophenyl)dihydropyrimidine-2,4(1H,3H)-dione	1517523-15-7	303.54
CH57002	Lenalidomide	191732-72-6	259.26
CH57003	Tasisulam	519055-62-0	415.1
CH57004	Indisulam	165668-41-7	385.8
CH57005	Chloroquinoxaline sulfonamide	97919-22-7	334.8
CH57006	LTbetaR-IN-1	2189366-77-4	320.35
CH57007	JH-RE-06	1361227-90-8	468.7
CH57008	NRX-103094	2763260-36-0	503.3
CH57009	dCeMM1	118719-16-7	369.24
CH57010	(S)-Lenalidomide	202271-91-8	259.26

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常见问题

Molecular Glues相关的定制合成、工艺开发、分析资料与项目沟通问题。

How do molecular glues differ from PROTACs?

Molecular glues are single small molecules that stabilize a protein-protein interaction, often between an E3 ligase and a neosubstrate. PROTACs are bifunctional molecules with a target ligand and E3 ligand connected by a linker.

What is a neosubstrate?

A neosubstrate is a protein recruited to an E3 ligase in the presence of a molecular glue, leading to ubiquitination and degradation in the relevant biological system.

Can CHEMOS support molecular glue analog synthesis?

CHEMOS can review custom analog synthesis, scaffold modification, linker-ready handle installation, and route development according to the target structure.

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