ADC linker
製品一覧
| カタログ番号 | 名称 | CAS番号 | 構造 | 分子量 | 購入 |
|---|---|---|---|---|---|
| CH53001 | Fmoc-8-amino-3,6-dioxaoctanoic acid | 166108-71-0 |  | 385.41 | |
| CH53002 | Maleimide | 541-59-3 |  | 97.07 | |
| CH53003 | Boc-C16-COOH | 843666-40-0 |  | 370.57 | |
| CH53004 | Boc-Hyp-OH | 13726-69-7 |  | 231.25 | |
| CH53005 | Eicosanedioic acid | 2424-92-2 |  | 342.51 | |
| CH53006 | Bis-PEG6-NHS ester | 1526718-98-8 |  | 576.55 | |
| CH53007 | 20-(tert-Butoxy)-20-oxoicosanoic acid | 683239-16-9 |  | 398.62 | |
| CH53008 | Boc-Val-Ala-PAB-PNP | 1884578-00-0 |  | 558.58 | |
| CH53009 | H-Glu-OtBu | 45120-30-7 |  | 203.24 | |
| CH53010 | Azetidin-3-ol hydrochloride | 18621-18-6 |  | 109.55 |
Technical Questions
Frequently Asked Questions
Common questions about custom synthesis, process development, analytical information, and project discussion for ADC linker.
What is the difference between cleavable and non-cleavable ADC linkers?
Cleavable linkers are designed to release payloads in response to intracellular triggers such as enzymes, pH, or reducing conditions. Non-cleavable linkers typically require degradation of the antibody component before payload release. The choice depends on payload, target biology, and conjugation strategy.
When should I use SMCC, maleimide-PEG, or DBCO chemistry?
SMCC and maleimide linkers are commonly used for lysine or cysteine conjugation strategies. PEG-spaced maleimides may improve solubility, while DBCO-azide chemistry supports copper-free click conjugation when azide handles are available.
Can CHEMOS support custom ADC linker synthesis?
Yes. CHEMOS can review custom linker synthesis, functional-handle installation, purification strategy, and analytical requirements according to the target structure and project stage.
What scale of ADC linker can CHEMOS support?
Batch size and availability depend on linker complexity, starting-material access, and specification requirements. Scale-up planning can be discussed after technical review.
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