DOPE
化学名称
[(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
DOPE•LNP
Structure: 
产品编号
CH51011
CAS
4004-05-1
分子式
C41H78NO8P
分子量
744.05
规格标准
| Catalog No. | CH51011 |
| CAS No. | 4004-05-1 |
| Molecular Formula | C41H78NO8P |
| Molecular Weight | 744.05 |
品类工艺支持
CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.
概况
DOPE (also known as [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate) (CAS 4004-05-1, MF C41H78NO8P, MW 744.05) belongs to the helper phospholipid class used in nucleic acid delivery system research and liposomal drug carriers. Typical chemistry topics include stereo-purity at the glycerol backbone, residual free fatty acid, and related diacyl regio-isomers. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.
应用
- DOPE (CAS 4004-05-1) preparation, route refinement, and analytical-control planning
- Helper phospholipid component in LNP and liposomal formulation research
- Pulmonary surfactant and biophysical research applications
- Process-development support for scalable phospholipid preparation