NH2-PEG4-DOTA
化学名称
2-[4-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
NH2-PEG4-DOTA•DOTA
Structure: 
产品编号
CH54004
CAS
2090232-34-9
分子式
C26H50N6O11
分子量
622.71
规格标准
| Catalog No. | CH54004 |
| CAS No. | 2090232-34-9 |
| Molecular Formula | C26H50N6O11 |
| Molecular Weight | 622.71 |
品类工艺支持
CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.
概况
NH2-PEG4-DOTA (also known as 2-[4-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 2090232-34-9, MF C26H50N6O11, MW 622.71) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
应用
- NH2-PEG4-DOTA (CAS 2090232-34-9) preparation, route refinement, and analytical-control planning
- Antibody and peptide radiolabeling research
- Custom synthesis of mono-functionalised DOTA derivatives
- Trace-metal control studies for radiopharmaceutical conjugates