Oligonucleotide Conjugation & Delivery Ligands

L96 Block 1 (DMT-Protected Pyrrolidine Linker Acid)

Oligonucleotide Conjugation & Delivery Ligands

产品编号CH67012CAS号1159408-70-4纯度>=97%

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产品概述

快速信息

产品系列: Oligonucleotide Conjugation & Delivery Ligands
分子式: C38H49NO7
分子量: 631.8
纯度: >=97%

CH67012 is a DMT-protected chiral pyrrolidine linker acid, also known as L96 Block 1 and (3R,5S)-5-O-DMT-3-pyrrolidinol-12-oxododecanoic acid. Its identifiers are CAS 1159408-70-4, molecular formula C38H49NO7, molecular weight 631.8, and PubChem CID 57874622.

The structure contains a terminal carboxylic acid, a free secondary alcohol on the pyrrolidine ring, and a hydroxymethyl group protected as a dimethoxytrityl (DMT) ether. These differentiated functional groups make it an upstream linker/scaffold intermediate for staged L96 conjugation chemistry.

Some supplier catalogs call this material "Peracetylated GalNAc-L96-Acid-2." That name is retained as a catalog alias only: the CAS-resolved structure does not contain a GalNAc sugar or acetate ester groups.

同义词

L96 Block 1; G1-20; Peracetylated GalNAc-L96-Acid-2 (supplier alias only)

身份与规格

Catalog No.	CH67012
CAS No.	1159408-70-4
Molecular Formula	C38H49NO7
Molecular Weight	631.8
PubChem CID	57874622
InChIKey	CEYLTMDXADTBEL-JHOUSYSJSA-N
Canonical Name	12-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxypyrrolidin-1-yl]-12-oxododecanoic acid
Purity	>=97%

储存条件

-20 +/- 5 C

技术属性

Building-block class: DMT-protected chiral pyrrolidine linker acid
Protected functionality: Hydroxymethyl group as DMT ether
Exposed handles: Terminal carboxylic acid and secondary alcohol
Assembly role: Upstream L96 scaffold intermediate
Packaging: 10 mg; 50 mg; 100 mg; 250 mg; 1 g; 5 g; 10 g; 50 g; 100 g; 500 g; 1 kg; 5 kg; 7 kg; 10 kg; 15 kg; 25 kg; Custom packaging on request
Physical form: white to light yellow powder
Stability: powder 3 years; in solvent at -80 C for 1 year

应用背景

L96 linker/scaffold assembly: an upstream protected pyrrolidine block used in L96-related conjugation chemistry.
Carboxylic-acid coupling: the terminal carboxylic acid provides a defined handle for amide-forming or related coupling steps.
Staged hydroxyl functionalization: the pyrrolidine secondary alcohol remains available while the hydroxymethyl group is protected as a DMT ether.

公开来源

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
PubChem 化合物 57874622
PubChem · CID 57874622

常见问题

What is CH67012 used for?

It is a DMT-protected chiral pyrrolidine linker acid used as an upstream L96 scaffold intermediate. The terminal carboxylic acid and free secondary alcohol provide differentiated reaction handles while the hydroxymethyl group remains DMT-protected.

Does CAS 1159408-70-4 contain a GalNAc sugar or acetate protecting groups?

No. PubChem CID 57874622 resolves this CAS to C38H49NO7, a DMT-protected pyrrolidine linker acid with no GalNAc sugar and no acetate ester. 'Peracetylated GalNAc-L96-Acid-2' is a supplier catalog alias, not a literal structural description.