2'-O-NMA-G (iBu) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C47H59N8O10P
- 分子量
- 927.0
- 纯度
- >=98% (HPLC)
2'-O-NMA-G (iBu) CE Phosphoramidite is a 2'-modified RNA building block: 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyrylguanosine with a 2'-O-[2-(methylamino)-2-oxoethyl] group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. It is identified by CAS 1025783-22-5, molecular formula C47H59N8O10P, molecular weight 927.0, PubChem CID 168441196, and InChIKey BNLNDNDXCOPBTF-NCJSJSGWSA-N.
"NMA" denotes the 2'-O-N-methylacetamide group (2'-O-CH2-C(=O)-NH-CH3), a permanent 2'-O-modification rather than a protecting group. The cited 2'-modification literature is used here as background for the 2'-position modification class, not as a standalone performance claim for this catalog item. The monomer couples through a standard 3'-phosphoramidite (3'→5' linkages), the 5'-DMT is removed each cycle, and the N2-isobutyryl base-protecting group is removed during final deprotection.
同义词
5'-O-DMT-N2-iBu-2'-O-[2-(methylamino)-2-oxoethyl]guanosine 3'-CE phosphoramidite; 2'-O-(N-methylcarbamoylmethyl)-guanosine amidite
身份与规格
| Catalog No. | CH65083 |
| CAS No. | 1025783-22-5 |
| Molecular Formula | C47H59N8O10P |
| Molecular Weight | 927.0 |
| PubChem CID | 168441196 |
| InChIKey | BNLNDNDXCOPBTF-NCJSJSGWSA-N |
| Purity | >=98% (HPLC) |
储存条件
<=-20 C
技术属性
- Monomer class
- 2'-O-NMA CE phosphoramidite
- Nucleobase
- Guanine
- Sugar modification
- 2'-O-(N-methylacetamide)
- Base protection
- N2-isobutyryl
- Packaging
- 1 g; 5 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white or off-white to faint yellow powder
- Stability
- stable under recommended storage conditions
应用背景
- 2'-O-N-methylacetamide (NMA) modification: a permanent 2'-O-amide substituent at the 2'-position.
- 2'-modification literature context: the cited literature supports the broader 2'-position modification class; avoid rewriting it as a standalone performance claim for this catalog item.
- 3'→5' coupling monomer: the 3'-phosphoramidite couples to form 3'→5' linkages; the 5'-DMT is removed each cycle and the N2-isobutyryl base-protecting group is removed during final deprotection.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 168441196
PubChem · CID 168441196
常见问题
What does 'NMA' stand for in this monomer?
NMA is the 2'-O-N-methylacetamide group — a 2'-O-CH₂-C(=O)-NH-CH₃ substituent (2'-O-[2-(methylamino)-2-oxoethyl]). It is a permanent 2'-O-modification, not a protecting group.
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