Fmoc-8-amino-3,6-dioxaoctanoic acid
化学名称
2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid
Fmoc-8-amino-3,6-dioxaoctanoic acid•ADC linker
Structure: 
产品编号
CH53001
CAS
166108-71-0
分子式
C21H23NO6
分子量
385.41
规格标准
| Catalog No. | CH53001 |
| CAS No. | 166108-71-0 |
| Molecular Formula | C21H23NO6 |
| Molecular Weight | 385.41 |
品类工艺支持
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
概况
Fmoc-8-amino-3,6-dioxaoctanoic acid (also known as 2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid) (CAS 166108-71-0, MF C21H23NO6, MW 385.41) is an antibody-drug conjugate (ADC) linker or bioconjugation building block. Chemistry topics around such compounds typically cover the reactive handle (maleimide / NHS / DBCO / azide), linker stability in plasma, and release behaviour intracellularly. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
应用
- Fmoc-8-amino-3,6-dioxaoctanoic acid (CAS 166108-71-0) preparation, route refinement, and analytical-control planning
- Click-chemistry coupling (DBCO / azide) for bioconjugation programs
- Process-development support for scalable linker preparation
- Bioconjugation handle for site-specific cysteine / lysine attachment