Maleimide
化学名称
pyrrole-2,5-dione
Maleimide•ADC linker
Structure: 
产品编号
CH53002
CAS
541-59-3
分子式
C4H3NO2
分子量
97.07
规格标准
| Catalog No. | CH53002 |
| CAS No. | 541-59-3 |
| Molecular Formula | C4H3NO2 |
| Molecular Weight | 97.07 |
品类工艺支持
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
概况
Maleimide (also known as pyrrole-2,5-dione) (CAS 541-59-3, MF C4H3NO2, MW 97.07) is an antibody-drug conjugate (ADC) linker or bioconjugation building block. Chemistry topics around such compounds typically cover the reactive handle (maleimide / NHS / DBCO / azide), linker stability in plasma, and release behaviour intracellularly. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.
应用
- Maleimide (CAS 541-59-3) preparation, route refinement, and analytical-control planning
- Click-chemistry coupling (DBCO / azide) for bioconjugation programs
- Custom linker / payload-linker synthesis on request
- Process-development support for scalable linker preparation