Butyne-DOTA
化学名称
2-[4-[2-(but-3-ynylamino)-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
Butyne-DOTA•DOTA
Structure: 
产品编号
CH54009
CAS
2125661-62-1
分子式
C20H33N5O7
分子量
455.51
规格标准
| Catalog No. | CH54009 |
| CAS No. | 2125661-62-1 |
| Molecular Formula | C20H33N5O7 |
| Molecular Weight | 455.51 |
品类工艺支持
CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.
概况
Butyne-DOTA (also known as 2-[4-[2-(but-3-ynylamino)-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 2125661-62-1, MF C20H33N5O7, MW 455.51) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.
应用
- Butyne-DOTA (2125661-62-1) supply and analog preparation for research programs
- Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates
- DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)
- Process-development support for scalable chelator preparation