Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-Deoxyuridine

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

产品编号CH64005CAS号951-78-0纯度>99.0% (HPLC)

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
分子式: C9H12N2O5
分子量: 228.20
纯度: >99.0% (HPLC)

2'-Deoxyuridine (dU) is the uracil DNA nucleoside formed from uracil and 2-deoxy-β-D-ribose. CH64005 is listed under CAS 951-78-0, molecular formula C9H12N2O5, molecular weight 228.20, and PubChem CID 13712.

This record is distinct from uridine, the corresponding RNA nucleoside. In research literature, 2'-deoxyuridine appears as a substrate in thymidylate synthase activity assays and as a reference nucleoside for uracil-in-DNA and base-excision-repair studies.

同义词

2'-Deoxyuridine; deoxyuridine; dUrd; dU; 2'-deoxyribouridine

身份与规格

Catalog No.	CH64005
CAS No.	951-78-0
Molecular Formula	C9H12N2O5
Molecular Weight	228.20
PubChem CID	13712
InChIKey	MXHRCPNRJAMMIM-SHYZEUOFSA-N
Purity	>99.0% (HPLC)

储存条件

Room temperature; cool and dark place below 15 C; inert gas

技术属性

Nucleobase: Uracil
Sugar: 2'-Deoxyribose
Nucleoside class: Pyrimidine 2'-deoxyribonucleoside
Packaging: 1 g glass bottle with plastic insert; Custom packaging on request
Physical form: Solid; white to almost white powder to crystal

应用背景

Thymidylate synthase assay research: [5-³H]-2'-deoxyuridine is reported as the substrate in in situ thymidylate synthase activity assays.
Base-excision-repair studies: uracil arising from dU in DNA is removed by uracil-DNA glycosylase, placing deoxyuridine in uracil-in-DNA research contexts.
dU nucleoside reference: CH64005 provides the dU identity for nucleoside and oligonucleotide chemistry comparisons.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 13712
PubChem · CID 13712

常见问题

Is CH64005 the DNA or RNA nucleoside?

It is 2'-deoxyuridine (dU), the deoxyribonucleoside of uracil. The RNA counterpart, uridine, is listed separately by CHEMOS.

Why is 2'-deoxyuridine used in DNA-repair research?

Uracil that ends up in DNA (via dU/dUMP) is recognized and removed by uracil-DNA glycosylase, so 2'-deoxyuridine is a reference nucleoside in base-excision-repair studies.