CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2',3'-Dideoxycytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64016CAS号7481-89-2纯度>=98.0% (HPLC)
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产品概述

快速信息

产品系列
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C9H13N3O3
分子量
211.22
纯度
>=98.0% (HPLC)

2',3'-Dideoxycytidine (ddC) is a pyrimidine 2',3'-dideoxynucleoside with cytosine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64016 is identified by CAS 7481-89-2, molecular formula C9H13N3O3, molecular weight 211.22, and PubChem CID 24066.

After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property defines its chain-termination context in DNA-polymerase and dideoxy-sequencing research.

同义词

2',3'-Dideoxycytidine; ddC; zalcitabine (research reagent naming)

身份与规格

Catalog No.CH64016
CAS No.7481-89-2
Molecular FormulaC9H13N3O3
Molecular Weight211.22
PubChem CID24066
InChIKeyWREGKURFCTUGRC-POYBYMJQSA-N
Purity>=98.0% (HPLC)

储存条件

-20 C

技术属性

Nucleobase
Cytosine
Sugar
2',3'-Dideoxyribose
Nucleoside class
Pyrimidine dideoxynucleoside
Research role
Chain-terminator nucleotide precursor
Packaging
250 mg glass bottle with plastic insert; Custom packaging on request
Physical form
White to pale cream crystals or crystalline powder or powder

应用背景

  • Chain-terminator precursor: the corresponding ddCTP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
  • DNA-polymerase research: ddC provides the cytidine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
  • Dideoxynucleoside reference: CH64016 provides the 2',3'-dideoxycytidine identity for nucleoside chemistry comparisons.

相关技术资源

寡核苷酸修饰

用于 ASO、siRNA、guide RNA、适配体以及研究或标记项目的糖、碱基、骨架、末端和偶联修饰。

寡核苷酸合成

支持修饰单体、固相载体、硫化试剂、帽类似物和相关寡核苷酸合成输入物。

公开来源

常见问题

Why is 2',3'-dideoxycytidine a chain terminator?

It lacks a 3'-hydroxyl, so once its triphosphate is incorporated by DNA polymerase no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.

How is ddC different from 2'-deoxycytidine?

2'-Deoxycytidine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxycytidine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxycytidine is cataloged separately.

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