Oligonucleotide Synthesis, RNA Raw Materials & Modification

2',3'-Dideoxyuridine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64019CAS号5983-09-5纯度>=98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C9H12N2O4
分子量: 212.20
纯度: >=98%

2',3'-Dideoxyuridine (ddU) is a pyrimidine 2',3'-dideoxynucleoside with uracil attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64019 is identified by CAS 5983-09-5, molecular formula C9H12N2O4, molecular weight 212.20, and PubChem CID 65161.

Its corresponding triphosphate, ddUTP, has been reported to be incorporated into a growing DNA chain at dTTP sites and to inhibit further elongation in an in vitro chain-termination study. This supports a narrow nucleic-acid research context for the dideoxynucleoside.

同义词

2',3'-Dideoxyuridine; ddU

身份与规格

Catalog No.	CH64019
CAS No.	5983-09-5
Molecular Formula	C9H12N2O4
Molecular Weight	212.20
PubChem CID	65161
InChIKey	BTOTXLJHDSNXMW-POYBYMJQSA-N
Purity	>=98%

储存条件

0-10 C

技术属性

Nucleobase: Uracil
Sugar: 2',3'-Dideoxyribose
Nucleoside class: Pyrimidine dideoxynucleoside
Research role: Chain-terminator nucleotide precursor
Packaging: 250 mg; Custom packaging on request
Physical form: Solid; white to light yellow powder to crystal
Stability: >=4 years

应用背景

Chain-termination precursor: the corresponding ddUTP is reported to be incorporated into a growing DNA chain and inhibit further elongation in an in vitro study.
Nucleic-acid research: ddU provides the uridine dideoxynucleoside identity for in vitro chain-termination comparisons.
Dideoxynucleoside reference: CH64019 provides the 2',3'-dideoxyuridine identity for nucleoside chemistry comparisons.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 65161
PubChem · CID 65161

常见问题

What chain-termination evidence supports 2',3'-dideoxyuridine?

In an in vitro study, the corresponding ddUTP was incorporated into a growing DNA chain at dTTP sites and inhibited further elongation. This page keeps that evidence in a research-only context.

How is ddU different from 2'-deoxyuridine?

2'-Deoxyuridine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxyuridine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxyuridine is cataloged separately.